Planta Med 2000; 66(7): 647-650
DOI: 10.1055/s-2000-8623
Letter
Georg Thieme Verlag Stuttgart · New York

Antimicrobial Activity and Chemical Composition of the Bark Oil of Croton stellulifer, an Endemic Species from S. Tomé e Príncipe

Ana Paula Martins1 , Lígia R. Salgueiro1,*, Maria José Gonçalves1 , Roser Vila2 , Félix Tomi3 , Tomás Adzet2 , António Proença da Cunha1 , Salvador Cañigueral2 , Joseph Casanova3
  • 1 Lab. de Farmacognosia, Fac. de Farmácia, Universidade de Coimbra, Coimbra, Portugal
  • 2 Unitat de Farmacologia i Farmacognòsia, Fac. de Farmàcia, Universitat de Barcelona, Barcelona, Spain
  • 3 Equipe Chimie et Biomasse, URA CNRS 2053, Université de Corse, Ajaccio, France
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

Abstract

The composition and the antimicrobial activity of the bark oil of Croton stellulifer, an endemic and rare species of these islands (S. Tomé and Príncipe) are reported. Analysis was carried out by GC, GC/MS and 13C-NMR. The major constituents were α-phellandrene (15.4 - 18.6 %), p-cymene (14.4 - 17.7 %), linalool (12.0 - 12.6 %) and α-pinene (8.1 - 9.1 %). Kessane, a sesquiterpenoid oxide, not yet reported in the genus Croton, was identified by NMR. The essential oil of C. stellulifer was active against both bacterial and fungal strains, except Aspergillus niger.

References

  • 1 Watt  J M,, Breyer-Brandjwijk  M G.. The medicinal and poisonous plants of southern and eastern Africa. 2a Ed., E. & S. Livingstone Ltd. London,; 1962: 399-401
  • 2 Oliver-Bever  B.. Medicinal plants in tropical west Africa. Cambridge University Press, Cambridge,; 1986: 189
  • 3 Martins  A P,, Salgueiro  L R,, Vila  R,, Tomi  F,, Cañigueral  S,, Casanova  J,, Proença da Cunha  A,, Adzet  T.. Essential oil composition of four Piper species from S. Tomé e Príncipe.  Phytochemistry. 1998;;  49 2019-23
  • 4 Martins  A P,, Salgueiro  L R,, Vila  R,, Tomi  F., Cañigueral  S,, Casanova  J,, Proença da Cunha  A,, Adzet  T.. Essential oil composition of three Ocimum species traditionally used in S. Tomé e Príncipe.  Planta Medica. 1999;;  65 187-99
  • 5 Hagedorn  M L,, Brown  S M.. The constituents of cascarilla oil (Croton eluteria Bennet).  Flavour and Fragance Journal. 1991;;  6 193-204
  • 6 Weyerstahl  P,, Marschall-Weyerstahl  H,, Manteuffel  E.. Analysis of the sesquiterpene fraction of Cascarilla oil. In: 11th International Congress of Essential Oils, Fragrances and Flavours, Proceedings Vol. 5, Chemistry-Analysis, Structure and Synthesis. Bhattacharyya SC, Sen N, Sethi KL, editors Oxford & IBH Publishing Co. PVT. Ltd., New Delhi,; 1989: 43-8
  • 7 Tomi  F,, Bradesi  P,, Bighelli  A,, Casanova  J.. Computer-aided identification of individual components of essential oils using carbon-13 NMR spectroscopy.  Journal of Magnetic Resonance Analysis. 1995;;  1 25-34
  • 8 Formácek  V,, Kubeczka  K H.. Essential oils analysis by capillary gas cromatography and carbon - 13 NMR spectroscopy. John Wiley & Sons, Chichester,; 1982
  • 9 Craveiro  A A,, Rodrigues  A S,, Andrade  C HS,, Matos  F JA,, Alencar  J W,, Machado  M IL.. Volatile constituents of Brazilian Euphorbiaceae. Genus Croton. .  Journal of Natural Products. 1981;;  44 602-8
  • 10 Iio  H,, Matsumoto  Y,, Shimokata  K,, Shibata  K,, Tokoroyama  T.. Cascarillone: revised structure and total synthesis.  Journal of Chemical Society, Perkin Transactions. I 1989;;  I 1360-1
  • 11 Lawrence  B M.. Essential Oils 1992 - 1994. Allured publishing corporation, Carol Stream, U.S.A.,; 1995: 128-31
  • 12 Van Beek  T A,, Lelyveld  G P.. Confirmation of the structure of kessane by NMR spectroscopy.  Journal of Essential Oil Research. 1993;;  5 169-78
  • 13 Hinou  J B,, Harvala  C E,, Hinou  E B.. Antimicrobial activity screening of 32 common constituents of essential oils.  Pharmazie. 1989;;  44 302-3
  • 14 Prudent  D,, Perineau  F,, Bessiere  J M,, Michel  G,, Bravo  R.. Chemical analysis, bacteriostatic and fungistatic properties of the essential oil of the atoumau from Martinique (Alpina speciosa K. Schum.).  Journal of Essential Oil Research. 1993;;  5 255-64
  • 15 Council of Europe.. European Pharmacopoeia,. 3th edn., Strasbourg,; 1997: 121 - 2
  • 16 Salgueiro  L,, Vila  R,, Tomi  F,, Figueiredo  A C,, Barroso  J G,, Cañigueral  S,, Casanova  J,, Proença da Cunha  A,, Adzet  T.. Variability of essential oils of Thymus caespititius from Portugal.  Phytochemistry. 1997;;  45 307-11
  • 17 Salgueiro  L,, Vila  R,, Tomás  X,, Tomi  F,, Cañigueral  S,, Casanova  J,, Proença da Cunha  A,, Adzet  T.. Chemical polymorphism of the essential oil of Thymus carnosus from Portugal.  Phytochemistry. 1995;;  38 391-6
  • 18 Adams  R P.. Identification of essential oil components by gas chromatography/mass spectroscopy. Allured publishing corporation, Carol Stream, Illinois U.S.A.,; 1995
  • 19 McLafferty  F W,, Stauffer  D B.. Mass spectrometry library search system BenchTop/PBM, version 3.0, Palisade Co., Newfield , NY, 1993. Using this software the following data base was searched: McLafferty FW, Stauffer DB, The Wiley/NBS registry of mass spectral data, 5th ed., . Wiley and Sons New York, NY, 1991.
  • 20 Cruickshank  R,, Duguid  I P,, Marmion  B P,, Swain  R HA. . Microbiologia Médica, Vol. II, 4a ed., Fundação Calouste Gulbenkian, Lisboa,; 1975: 393-403

Prof. Dr. Lígia Salgueiro

Laboratório de Farmacognosia Faculdade de Farmácia de Coimbra

P-3000 Coimbra

Portugal

eMail: ligia@gemini.ci.uc.pt

Telefon: +351-239827126