Planta Med 2000; 66(7): 641-644
DOI: 10.1055/s-2000-8634
Letter
Georg Thieme Verlag Stuttgart · New York

Inhibitory Activity of Stilbenes from Medicinal Plants on the Expression of Cell Adhesion Molecules on THP1 Cells

Kyung-Seop Ahn1 , Jung-Hee Kim1 , Sei-Ryang Oh1 , Shi-Yong Ryu2 , Hyeong-Kyu Lee1,*
  • 1 Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
  • 2 Korea Research Institute of Chemistry and Technology, Taejon, Korea
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). A cell-to-cell adhesion assay showed that 3,5-dihydroxy-4′-methoxystilbene and 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucopyranoside as well as resveratrol blocked significantly TNF-α-inducing cell-cell adhesion between human umbilical vein endothelial cells (HUVEC) and THP-1 cells.

Abbreviations

ELISA:Enzyme linked immunoadsorbent assayFBS:Fetal bovine serumHUVEC:Human umbilical vein endothelial cellICAM-1:Intercellular adhesion molecule-1OPD:O-Phenylenediamine dihydrochloridePBS:Phosphate buffered salineTNF-α:Tumor necrosis factor-αVCAM-1:Vascular cell adhesion molecule-1

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Dr. Hyeong-Kyu Lee

Immunomodulator Research Lab. Korea Research Institute of Bioscience and Biotechnology

P.O. Box 115

Yusong

Taejon 305-600

Korea

Email: hykylee@mail.kribb.re.kr

Phone: +82-42-860-4608