CAL-B Catalyzed Enantioselective Synthesis of Cyanohydrins - A Facile Route to Versatile Building Blocks

Ulf Hanefeld; Yuxin Li; Roger A. Sheldon; Thomas Maschmeyer

doi:10.1055/s-2000-8673

Synlett 2000; 2000(12): 1775-1776
DOI: 10.1055/s-2000-8673

letter

© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

CAL-B Catalyzed Enantioselective Synthesis of Cyanohydrins - A Facile Route to Versatile Building Blocks

Ulf Hanefeld^* , Yuxin Li, Roger A. Sheldon, Thomas Maschmeyer

^*Applied Organic Chemistry and Catalysis, DelftChemTech, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft, The Netherlands; Fax +31-15-278 4289; E-mail: hanefeld@tnw.tudelft.nl

Abstract

PDF Download All articles of this category

A straightforward process for the preparation of optically active cyanohydrins, important building blocks for the synthesis of drugs and agrochemicals, has been established. Lipase B from Candida antarctica (CAL-B) catalyzes the kinetic resolution of racemic cyanohydrin acetates under mild conditions: optimization of the process led to a user-friendly synthesis of (S)- and (R)-cyanohydrins.

cyanohydrin - lipase - kinetic resolution - Candida antarctica - stereoselective synthesis

PDF (39 kb)