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Synthesis 2000; 2000(14): 2001-2003
DOI: 10.1055/s-2000-8718
short paper
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A Practical and Highly Efficient Synthesis of α-(Trimethylsilyl)-difluoroacetates

Hideki Amii* , Takeshi Kobayashi, Kenji Uneyama
  • *Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushimanaka 3-1-1, Okayama 700-8530, Japan; Fax +81(86)2 51 80 75; E-mail: uneyamak@cc.okayama-u.ac.jp
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Publication Date:
31 December 2000 (online)

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An efficient method for the gram scale preparation of α-(trimethylsilyl)difluoroacetates is described. The key step involves Mg(0)-promoted selective C-F bond cleavage of readily available trifluoroacetates.

magnesium - fluorine - silicon - esters - electron transfer