Download PDF
Synthesis 2000; 2000(14): 2092-2098
DOI: 10.1055/s-2000-8732
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of Enantioenriched Substituted Tetrahydrofurans and Tetrahydropyrans via Iron-Mediated Chirality Transfer and Ring Closure

Dieter Enders* , Duy Nguyen
  • *Institut für Organische Chemie, Rheinisch-Westfälische Technische Hochschule, Professor-Pirlet-Straße 1, D-52074 Aachen, Germany; Fax +49(241)8 88 81 27; E-mail: Enders@RWTH-Aachen.de
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The synthesis of optically active, functionalized tetrahydrofurans and tetrahydropyrans via Fe(CO)4-mediated cycloetherification has been accomplished. The ring closure reaction proceeds with chirality transfer and under retention of the configuration at the allylic carbon center.

cyclic ethers - allylic substitution - iron tetracarbonyl complexes - chirality transfer - enzymatic kinetic resolution - ring closure