Planta Med 2000; 66(7): 630-634
DOI: 10.1055/s-2000-8886
Original Paper

Georg Thieme Verlag Stuttgart · New York

Bioactive Triterpenoids from the Stem Bark of Picea glehni

Reiko Tanaka1, , Yoshitaka Kinouchi1 , Harukuni Tokuda2 , Hoyoku Nishino2 , Shunyo Matsunaga1
  • 1 Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
  • 2 Department of Biochemistry, Kyoto Prefectural University of Medicine, Kyoto, Japan
Further Information

Publication History

November 8, 1999

January 23, 2000

Publication Date:
31 December 2000 (online)

Abstract

Two new triterpenoids, 3α-methoxyserrat-14-en-21β-yl formate (1), and 24-methylcycloartenone (2), were isolated from the stem bark of Picea glehni (Fr. Schm.) Masters together with three known triterpenoids, 3α-methoxyserrat-14-en-21β-ol, 3β-methoxyserrat-14-en-21β-ol, and piceanonol A. Compounds 1, 2, and a synthetic sample, 3α-methoxyserrat-13-en-21β-yl formate showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).

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Reiko Tanaka

Department of Medicinal Chemistry Osaka University of Pharmaceutical Sciences

4-20-1 Nasahara Takatsuki Osaka 569-1094 Japan

Email: E-mail: tanakar@oysun01.oups.ac.jp

Fax: Fax: +81-726-90-1084