Bioactive Triterpenoids from the Stem Bark of Picea glehni

Abstract

Two new triterpenoids, 3α-methoxyserrat-14-en-21β-yl formate (1), and 24-methylcycloartenone (2), were isolated from the stem bark of Picea glehni (Fr. Schm.) Masters together with three known triterpenoids, 3α-methoxyserrat-14-en-21β-ol, 3β-methoxyserrat-14-en-21β-ol, and piceanonol A. Compounds 1, 2, and a synthetic sample, 3α-methoxyserrat-13-en-21β-yl formate showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).

Key words

Picea glehni - Pinaceae - serratane - cycloartane - 2D NMR - in vitro anti-tumor-promoting activity

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