Planta Med 2000; 66(8): 768-769
DOI: 10.1055/s-2000-9601
Letter

© Georg Thieme Verlag Stuttgart · New York

Antimicrobial Triterpenoids from Licania heteromorpha

Alessandra Braca1 , Ivano Morelli1 , Jeannette Mendez2 , Lucia Battinelli3 , Laura Braghiroli3 , Gabriela Mazzanti3,*
  • 1 Dipartimento di Chimica Bioorganica e Biofarmacia, Università degli Studi di Pisa, Pisa, Italy
  • 2 Escuela de Quimica, Universidad Central de Venezuela, Caracas, Venezuela
  • 3 Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, Università di Roma “La Sapienza”, Roma, Italy
Further Information

Publication History

December 2, 1999

May 13, 2000

Publication Date:
31 December 2000 (online)

Abstract

Six triterpenoids having a lupane and oleane skeleton were isolated from the leaves and young branches of Licania heteromorpha Bentham var. heteromorpha and were identified as: betulinic acid 1, alphitolic acid 2, 3β-O-trans-p-coumaroyl alphitolic acid 3, 3β-O-cis-p-coumaroyl alphitolic acid 4, 3β-O-trans-p-coumaroyl maslinic acid 5, 3β-O-cis-p-coumaroyl maslinic acid 6. The antimicrobial activity of these compounds was evaluated in vitro on clinically isolated microorganisms employing a microdilution method. Compounds 2, 3, 5, and 6 showed antimicrobial activity on Gram-positive bacteria and yeasts, whereas none of the six triterpenoids were active against Gram-negative organisms.

References

  • 1 Toledo C L, Kubitzki K, Prance G H. Flora de Venezuela. Vol IV Ediciones Fundacion Educacion Ambiental Caracas; 1982: 367-8
  • 2 Pittier H. Manual de las Plantas usuales de Venezuela. Caracas; Editorial Fundacion Eugenio Mendoza 1978: 579
  • 3 Suffness M, Abbott B, Statz D, Wonilowicz E, Spjut R. The utility of P388 leukemia compared to B16 melanoma and colon carcinoma 38 for in vivo screening of plant extract.  Phytotherapy Research. 1988;  2 89-97
  • 4 Hernàndez-Pèrez M, López-García R E, Rabanal R M, Darias V, Arias A. Antimicrobial activity of Visna mocanera leaf extracts.  Journal of Ethnopharmacology. 1994;  41 115-9
  • 5 Collins M A, Charles H P. Antimicrobial activity of carnosol and ursolic acid: two anti-oxidant constituents of Rosmarinus officinalis L.  Food Microbiology. 1987;  4 311-4
  • 6 Reher G, Budesinsky M. Triterpenoids from plants of the Sanguisorbeae.  Phytochemistry. 1992;  31 3909-14
  • 7 Siddiqui B S, Farhat Begum S, Siddiqui S. Isolation and structural elucidation of acylated pentacyclic triterpenoids from the leaves of Eucalyptus camaldulensis var. obtusa .  Planta Medica. 1997;  63 47-50
  • 8 Yagi A, Okamura N, Haraguchi Y, Noda K, Nishiota I. Studies on the constituents of Zizyphi Fructus. I. Structure of the three new p-coumaroylates of alphitolic acid.  Chemical and Pharmaceutical Bulletin. 1978;  26 1798-802
  • 9 Yagi A, Okamura N, Haraguchi Y, Noda K, Nishiota I. Studies on the constituents of Zizyphi Fructus. II. Structure of new p-coumaroylates of maslinic acid.  Chemical and Pharmaceutical Bulletin. 1978;  26 3075-9

Prof. Gabriela Mazzanti

Dipartimento di Farmacologia delle Sostanze

Naturali e Fisiologia Generale

Università di Roma “La Sapienza”

Piazzale Aldo Moro 5

00185 Rome

Italy

Email: gabriela.mazzanti@uniroma1.it

Fax: +39 06 49912480