Sesquiterpenes from the Leaves of Ligularia fischeri var. spiciformis

Hee-Juhn Park; Sang-Hyuk Kwon; Ki-Oug Yoo; Il-Cheol Sohn; Kyung-Tae Lee; Hyeong-Kyu Lee

doi:10.1055/s-2000-9602

Planta Medica, Table of Contents

Planta Med 2000; 66(8): 783-784
DOI: 10.1055/s-2000-9602

Letter

Sesquiterpenes from the Leaves of Ligularia fischeri var. spiciformis

Hee-Juhn Park^1,*, Sang-Hyuk Kwon¹ , Ki-Oug Yoo^{2, 5} , Il-Cheol Sohn³ , Kyung-Tae Lee³ , Hyeong-Kyu Lee⁴

¹ Faculty of Applied Plant Sciences, Sangji University, Wonju, Korea
² Department of Biology, Kangwon National University, Chuncheon, Korea
³ College of Pharmacy, Kyung-Hee University, Seoul, Korea
⁴ Biomaterial Research Division, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
⁵ Present address: Department of Biology, Colorado State University, Fort Collins, Colorado 80523, U.S.A.

Abstract

From the leaves of Ligularia fischeri var. spiciformis, a new eremophilanolide, 8α-methoxy-6-oxoeremophil-7(11)-en-12,8-olide (6-oxoeremophilenolide) and a eudesmane-type sesquiterpene, (+)-intermedeol were isolated. The structures were determined on the basis of 2D-NMR spectral data. Data on cytotoxicity showed that the latter was clearly more potent than the former compound.

Full Text

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Ass. Prof. Dr. Hee-Juhn Park

Faculty of Applied Plant Sciences

Sangji University

Wonju 220-702, Korea

Email: hjpark@chiak.sangji.ac.kr)

Fax: +82-+371-730-0564

Phone: +82-+371-730-0564