Planta Med 2000; 66(8): 765-767
DOI: 10.1055/s-2000-9774
Letter
© Georg Thieme Verlag Stuttgart · New York

Smooth Muscle Relaxing Activity of Gentiopicroside Isolated from Gentiana spathacea

Alejandra Rojas*, Moustapha Bah, J. Isela Rojas, Dora M. Gutiérrez
  • Facultad de Química, Universidad Autónoma de Querétaro, Centro Universitario, Querétaro, México
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Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

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Abstract

Bioassay directed fractionation of the (1 : 1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of isolated guinea pig ileum. Contractions induced by histamine, acetylcholine, BaCl2 and KCl on the ileum were also significantly blocked by this monoterpene glucoside, which suggests that this compound might be interfering with calcium influx into the smooth muscle cells.

References

Dr. M. Alejandra Rojas
Molina

Departamento de Investigación Química y Farmacológica de Productos Naturales Facultad de Química Universidad Autónoma de Querétaro

Cerro de las Campanas 76010

Querétaro

Mexico

eMail: rojasa@sunserver.uaq.mx

Telefon: +52 42 163730