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Synlett 2001; 2001(2): 0278-0280
DOI: 10.1055/s-2001-10760
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Synthetic Access to Biologically Active Butenolides from Streptomyces antibioticus

Gilles Grossmann* , Urs Séquin
  • *Institut für Organische Chemie der Universität Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland; Tel. +41 61 267 11 10; Fax +41 61 267 11 03; E-mail: urs.sequin§unibas.ch
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Publication Date:
31 December 2001 (online)

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A synthetic route to a class of substituted butenolides isolated from Streptomyces antibioticus has been elaborated. The process involves coupling of the readily available methylated furanone 5 with aldehydes.

furanones - Streptomyces antibioticus - natural products - equilibrating hemiacetals - nucleophilic additions