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Synthesis 2001; 2001(2): 0247-0250
DOI: 10.1055/s-2001-10814
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Homochiral 2-Aminoadipates and 6-Oxopipecolates From Glutamic Acid

Ian G. C. Coutts* , Robert E. Saint, Sandra L. Saint, David M. Chambers-Asman
  • *Department of Chemistry and Physics, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK; Fax 44(0)1158486636; E-mail: ian.coutts§ntu.ac.uk
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Publication Date:
31 December 2001 (online)

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A modified Arndt-Eistert procedure provides a safe and convenient synthesis of homo-chiral N-alkoxycarbonyl α-ethyl aminoadipates and ethyl 6-oxopipecolates in reasonable yield.

ring-opening - N-alkoxycarbonyl-protected lactams - Wolff rearrangement - aminoadipate - 6-oxopipecolate