Download PDF
Synthesis 2001; 2001(2): 0276-0280
DOI: 10.1055/s-2001-10815
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

5-Isoxazolecarboxaldehyde: A Novel Substrate for Fast Baylis-Hillman Reaction

Arundhati Patra* , Sanjay Batra, Bijoy Kundu, Bhawani Shankar Joshi, Raja Roy, Amiya Prasad Bhaduri
  • *Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India; Fax +91(522)223405, +91(522)223938; E-mail: batra_san§yahoo.co.uk, root§cscdri.ren.nic.in
Further Information

Publication History

Publication Date:
31 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

3-Aryl-5-isoxazolecarboxaldehyde undergoes fast Baylis-Hillman reaction with a variety of activated alkenes to yield the corresponding adducts in excellent yields. Some of the Baylis-Hillman adducts reported herein have been subsequently modified to obtain isoxazole substituted pyrazolin-3-ones and γ-butyrolactones.

5-isoxazolecarboxaldehyde - Baylis-Hillman reaction - pyrazolin-3-ones - HTIB - γ-butyrolactones