Planta Med 2001; 67(1): 49-54
DOI: 10.1055/s-2001-10876
Original Paper
Georg Thieme Verlag Stuttgart · New York

Effects of Saponins on the Water Solubility of Different Model Compounds

Ute Walthelm1 , Katharina Dittrich1 , Götz Gelbrich2 , Thomas Schöpke1,*
  • 1 Institut für Pharmazie, Mathematisch-Naturwissenschaftliche Fakultät, Ernst-Moritz-Arndt-Universität, Greifswald, Germany
  • 2 Institut für Mathematik, Mathematisch-Naturwissenschaftliche Fakultät, Ernst-Moritz-Arndt-Universität, Greifswald, Germany
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2001 (online)

Abstract

The influence of saponins on the water solubility of compounds having poor aqueous solubility was investigated with the model compounds digitoxin, rutin and aesculin. The saponins that were tested represent the most abundant structural types. Only slight effects on aqueous solubility were obtained for all the model compounds. These effects include both enhancements and reductions in aqueous solubility depending on the saponin, the concentration of the saponin solution and the model compound. Structure-activity relationships of general significance were not observed. Hence, saponins generally should not be regarded as solubilizers.

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Dr. PD Thomas Schöpke

Institut für Pharmazie

Mathematisch-Naturwissenschaftliche Fakultät

Ernst-Moritz-Arndt-Universität

Friedrich-Ludwig-Jahn-Str. 15a

17487 Greifswald

Germany

eMail: thomas@schoepke.de

Telefon: +49-3838-864885