PDF herunterladen
Synthesis 2001; 2001(3): 0364-0366
DOI: 10.1055/s-2001-11427
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Convenient Synthesis of 3,7-Diazabicyclo[3.3.1]nonane (Bispidine)

Yuji Miyahara* , Kenta Goto, Takahiko Inazu
  • *Department of Chemistry, Faculty of Science, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Fax + 81(92)6 42 26 07; E-mail: miyahscc@mbox.nc.kyushu-u.ac.jp
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2001 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Bispidine 1a is conveniently synthesized via a route involving double Mannich reaction of 1-allylpiperidin-4-one to N,N′-diallylbispidinone, Wolff-Kishner reduction of the bispidinone, and deallylation of the resulting N,N′-diallylbispidine by treatment with ethyl chloroformate in the presence of NaI, followed by alkaline hydrolysis.

bicyclic compounds - Dieckman condensation - double Mannich reaction - deallylation