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Planta Med 2001; 67(2): 166-168
DOI: 10.1055/s-2001-11501
DOI: 10.1055/s-2001-11501
Letter
© Georg Thieme Verlag Stuttgart · New York
Lignans as Anti-Tumor-Promoter from the Seeds of Hernandia ovigera
Further Information
Publication History
March 23, 2000
June 18, 2000
Publication Date:
31 December 2001 (online)
![](https://www.thieme-connect.de/media/plantamedica/200102/lookinside/thumbnails/10.1055-s-2001-11501-1.jpg)
Abstract
Seven lignans (2 - 8) isolated from the seeds of Hernandia ovigera L. (Hernandiaceae) were tested for their inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. Using a primary screening test, all the lignans showed inhibitory activity with IC50 470 - 590 mol ratio/32 pmol TPA. The data demonstrated that these lignans might be valuable anti-tumor-promoters.
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Masataka Itoigawa,Ph.D.
Tokai Gakuen University
Ukigai
Miyoshi-cho
Nishikamo-gun
Aichi 470-0207
Japan
Email: itoigawa@tokaigakuen-c.ac.jp
Fax: +81-5613-6-6757