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DOI: 10.1055/s-2001-11510
© Georg Thieme Verlag Stuttgart · New York
Neuroprotective Effects in Gerbils of Spiramine T from Spiraea japonica var. acuta
Publikationsverlauf
March 23, 2000
July 16, 2000
Publikationsdatum:
31. Dezember 2001 (online)
![](https://www.thieme-connect.de/media/plantamedica/200102/lookinside/thumbnails/10.1055-s-2001-11510-1.jpg)
Abstract
The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were investigated. Intravenous spiramine T (0.38, 0.75, and 1.5 mg · kg-1) markedly reduced the stroke index, enhanced the recovery of EEG amplitude during reperfusion and decreased the concentrations of cortex calcium and LPO in a dose-dependent manner. However, no significant effects on water and sodium contents were observed. These results suggested that spiramine T exhibited protective effects on cerebral ischemia-reperfusion injury in gerbils, and its mechanism might be related to reducing calcium accumulation and lipid peroxidation. This is the first report on spiramine T as a natural product with neuroprotective effects.
Abbreviations
AA:arachidonic acid
EEG:electroencephalogram
LPO:lipid peroxide
MDA:malondialdehyde
PAF:platelet activating factor
Key words
Spiraea japonica var. acuta - Rosaceae - spiramine T - cerebral ischemia-reperfusion - stroke index - electroencephalogram - calcium - lipid peroxide
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Xiao-Jiang Hao
Kunming Institute of Botany
Chinese Academy of Sciences
Heilongtan
Kunming 650204
Yunnan
China
eMail: xjhao@mail.kib.ac.cn
Telefon: Tel: +86-871-5150227