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Planta Med 2001; 67(2): 179-181
DOI: 10.1055/s-2001-11513
Letter

© Georg Thieme Verlag Stuttgart · New York

Modulatory Effect of Aliphatic Acid Amides from Zanthoxylum piperitum on Isolated Gastrointestinal Tract

Kazunori Hashimoto1,*, Kazuko Satoh1 , Yoshio Kase1 , Atsushi Ishige1 , Masayoshi Kubo1 , Hiroshi Sasaki1 , Shigeto Nishikawa2 , Susumu Kurosawa2 , Koji Yakabi2 , Takashi Nakamura2
  • 1 Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan
  • 2 The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan
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Publication History

March 23, 2000

July 16, 2000

Publication Date:
31 December 2001 (online)

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Abstract

β-Sanshool and γ-sanshool, unsaturated aliphatic acid amides isolated from the pericarpium of Zanthoxylum piperitum De Candolle (Rutaceae), relax the circular muscle of the gastric body, as well as contract the longitudinal muscle of the ileum and distal colon in an experimental system using the gastrointestinal tract isolated from a guinea pig.

References

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Dr. Kazunori Hashimoto

Kampo & Pharmacognosy Laboratory

3586 Yoshiwara

Ami-machi

Inashiki-gun

Ibaraki 300-11

Japan

Email: hashimoto_kazunori@mail.tsumura.co.jp

Fax: +81-298-89-3832