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Synlett 2001; 2001(4): 0509-0512
DOI: 10.1055/s-2001-12334
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Intramolecular Oxonium-Ene-Type Reaction of a Bis(Alkyne-Dicobalt Hexacarbonyl) Complex

Gyles Darren Smyth* , Hirofumi Ohmura, Koichi Mikami
  • *Department of Applied Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8552, Japan; Fax + 81 3 5734 2776; E-mail: kmikami@o.cc.titech.ac.jp
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Publication Date:
31 December 2001 (online)

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An intramolecular ene-type cyclization of a bis(alkyne-dicobalt hexacarbonyl) complex via an oxonium ion is described. This cyclization can be used in an approach to the synthesis of the medium-ring enediyne cores found in NCS chromophore, C-1027, and kedarcidin, employing an intramolecular oxonium-ene-type reaction.

cyclization - medium-ring - oxonium-ene reaction - alkyne dicobalt hexacarbonyl - enediyne core