An investigation was made to evaluate the role of Convolvulus pluricaulis root extract in the regulation of hyperthyroidism in female mice. Its possible site of action was also studied. L-Thyroxine treatment for 30 days increased serum concentrations of thyroxine (T4) and triodothyronine (T3). The activity of hepatic 5’-monodeiodinase (5’-DI) and glucose-6-phosphatase (G-6-Pase) was also enhanced. On the other hand, administration of the plant extract either alone or with L-T4, decreased serum T3 concentration and the activity of hepatic 5’-DI and G-6-phase, without marked alteration in hepatic lipid peroxidation, indicating the possible regulation of hyperthyroidism by the plant extract. It appears that the action of the plant extract on thyroid function is primarily mediated through the inhibition of 5’-DI enzyme activity.
Key words:
L-Thyroxine - Convolvulus pluricaulis - Triodothyronine - 5’-Monodeiodinase - Lipid peroxidation - Glucose-6-phosphatase
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Dr. A Kar
Thyroid Research Unit, School of Life Sciences
Devi Ahilya University,
Khandwa Road
Indore-452017
India
Phone: Phone:+ 0091 (731) 467029
Fax: Fax:+ 0091 (731) 472793
