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DOI: 10.1055/s-2001-12711
Einflussfaktoren auf die Anastomosenheilung
Factors that Influence Anastomis HealingPublikationsverlauf
Publikationsdatum:
18. Mai 2004 (online)
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Zusammenfassung.
Die Anastomosenheilung kann in ihrem regelhaften Verlauf von einer Vielzahl unterschiedlicher Faktoren beeinflusst werden. Dabei ist von übergeordneter Bedeutung die Herstellung einer primär gas- und luftdichten, spannungslosen und gut durchbluteten Naht. Der Operateur und seine individuelle Operationstechnik insgesamt, aber weniger die gewählte Anastomosierungstechnik an sich spielt somit eine entscheidende Rolle. Daneben kann das Heilungsergebnis durch eine Reihe weiterer lokaler und allgemeiner Faktoren beeinflusst werden, deren praktische Relevanz für die Klinik allerdings im Einzelnen nur zum Teil gesichert ist. Dennoch ist ihre Kenntnis und Beachtung wegen der durch den Faktorensynergismus bestimmte Einflussnahme auf das Heilungsergebnis wichtig. Der Wunsch nach einer medikamentösen Heilungsmodulation käme vor allem Risikoanastomosen zugute, konnte aber bislang nur partiell erfüllt werden.
Factors that Influence Anastomis Healing.
Normal anastomotic healing can be influenced by numerous different factors. Achieving a primary gas tight, tension free and well perfused suture is of major importance. This is why the surgeon and his own surgical technique rather than the chosen technique of anastomosis play the leading role in anastomotic healing. In addition to this, the healing result may be influenced by a number of other local or general factors. The clinical relevance of most of these factors, however, has not been proven in prospective studies. Nonetheless, it appears to be most important to know and obey these factors, since they do influence the healing result. The goal of drug assisted anastomotic healing is of special healing for anastomoses in risk patients. This goal, however, has only been reached partially until today.
Schlüsselwörter:
Anastomosen - Anastomosenheilung - Anastomosentechnik - Einflussfaktoren - Gastrointestinaltrakt
Key words:
Anastomoses - anastomotic healing - influencing factors - technique of anastomoses - gastro intestinal tract
Literaturverzeichnis
- 1 Langer S, Kupczyk D. Entstehung der Nahtinsuffizienz. Langenbecks Arch Chir (Kongreßbericht 1982):. 1982; 358 253-258
- 2 Meyer G, Lang R A. Anastomosenheilung. Viszeralchirurgie. 2000; 35 153-165
- 3 Jacobs G, Ulrich B. Klammernahtgeräte am Magen und Dünndarm. Langenbecks Arch Chir. 1981; 355 465-469
- 4 Bell C M, Lewis C B. Effect of neostigmine on integrity of iliorectal anastomoses. Br Med J. 1968; 3 587-588
- 5 Brolin R E, Ravitch M M. Studies in intestinal healing VI. Effect of pharmacologically induced peristalsis on fresh intestinal anastomoses in dogs. Arch Surg. 1980; 115 339-343
-
6 Scheele J.
Grundlagen der Anastomosenheilung . In: Scheele J (Hrsg) Fibrinklebung. Springer Berlin Heidelberg New York Tokyo; 1984: S 115-119 - 7 Ballantyne G H. Intestinal suturing - review of the experimental foundations for traditional doctrines. Dis Colon Rectum. 1983; 26 836-843
- 8 Jiborn H, Ahonen J, Zederfeldt B. Healing of experimental colonic anastomoses. IV. Effect of suture technique on collagen metabolism in the colonic wall. Am J Surg. 1980; 139 406-413
-
9 Zederfeldt B, Jiborn H, Blomquist P.
Effects of different suture techniques on healing of experimental colonic anastomoses . In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S. 110-121 - 10 Arbogast R, Gay B, Höcht B. Der Einfluß des Nahtmaterials auf die mechanische Belastbarkeit von Darmanastomosen. Chirurg. 1978; 49 640-644
-
11 Debus E S, Lünstedt B, Geiger D, Schultz U, Thiede A.
Handnaht, Klammernaht und Kompressionsanastomose - eine kontrollierte, vergleichende Untersuchung von 3 Anastomosenverfahren am Kolon des Schweines. In: Thiede A, Lünstedt B (Hrsg) Standards in der Viszerosynthese. Springer Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest; 1994: S. 24-31 - 12 Czerny V. Zur Darmresektion. Berl klin Wschr. 1880; 17 637-642-683-684
- 13 Halsted W S. Circular suture of the intestine - an experimental study. Am J Med Sci. 1887; 94 436-461
- 14 Buchin R, van Geertruyden J. Valeur comparée des sutures intestinales en un plan et en deux plans. Etude expérimentale et clinique. Acta Chir Belg. 1960; 59 461-480
- 15 Chung R S. Gastrointestinal anastomoses constructed with singly placed staples. Am J Surg. 1980; 139 876-879
- 16 Ellison G W. Wound healing in the gastrointestinal tract. Semin Vet Med Surg. 1989; 4 287-293
- 17 Graffner H, Andersson L, Löwenhielm P, Walther B. The healing process of anastomoses of the colon. A comparative study using single, double-layer or stapled anastomosis. Dis Colon Rectum. 1984; 27 767-771
- 18 Letwin E, Williams H YG. Healing of intestinal anastomosis. Can J Surg. 1967; 10 109-116
- 19 McAdams A J, Meikle G, Medina R. An experimental comparison of inversion and eversion colonic anastomoses. Dis Colon Rectum. 1969; 12 1-6
- 20 Yesilkaya Y, Soyhan N, Bengisu N, Sen M, Aritas Y. The effects of different suture techniques on collagen metabolism in experimental distal colonic anastomoses. Br J Surg. 1985; 72 987-989
- 21 Hamilton J E. Reappraisal of open intestinal anastomoses. Ann Surg. 1967; 165 917-924
- 22 Müller G, Kieninger G, Breucha G, Bustamante I, Neugebauer W. Vergleichende Untersuchungen ein- und zweireihiger Anastomosen am Schweinedünndarm. Langenbecks Arch Chir. 1978; 346 37-45
- 23 Nakanishi H. Experimental gut anastomoses and their revascularization. Aust NZ J Surg. 1975; 45 309-314
- 24 Jansen A, Becker A E, Brummelkamp W H, Keeman J N, Klopper P J. The importance of the apposition of the submucosal intestinal layers for primary wound healing of intestinal anastomosis. Surg Gynecol Obstet. 1981; 152 51-58
- 25 Ravitch M M. Observations on the healing of wounds of the intestines. Surgery. 1975; 77 665-673
- 26 Herrmann J B, Woodward S C, Pulaski E J. Healing of colonic anastomoses in the rat. Surg Gynecol Obstet. 1964; 119 269-275
- 27 Orr N WM. A single-layer intestinal anastomosis. Br J Surg. 1969; 56 771-774
- 28 Irvin T T, Edwards J P. Comparison of single-layer inverting, two-layer inverting, and everting anastomoses in the rabbit colon. Br J Surg. 1973; 60 453-457
- 29 Stoloff D, Snider III T G, Crawford M P, Taylor H W, Cox H U. End-to-end colonic anastomosis. A comparison of techniques in normal dogs. Vet Surg. 1984; 13 76-82
- 30 Högström H, Haglund U, Zederfeldt B. Suture technique and early breaking strength of intestinal anastomoses and laparotomy wounds. Acta Chir Scand. 1985; 151 441-443
- 31 Bronwell A W, Rutledge R, Dalton Jr M L. Single-layer open gastrointestinal anastomosis. Ann Surg. 1967; 165 925-932
- 32 Goligher J C. Visceral and parietal suture in abdominal surgery. Am J Surg. 1976; 131 130-140
- 33 Goligher J C, Lee PWG; Simpkins K C, Lintott D J. A controlled comparison of one- and two-layer techniques of suture for high and low colorectal anastomoses. Br J Surg. 1977; 64 609-614
- 34 Heifetz C J. Technique of single-layer end-to-end intestinal anastomosis by triangulation. Surg Clin N Am. 1966; 46 223-228
- 35 Irvin T T, Goligher J C, Johnston D. A randomized prospective clinical trial of single-layer and two-layer inverting intestinal anastomoses. Br J Surg. 1973; 60 457-460
- 36 Jiborn H, Ahonen J, Zederfeldt B. Healing of experimental colonic anastomoses. II. Breaking strength of the colon after left colon resection and anastomosis. Am J Surg. 1978; 136 595-599
- 37 Olinger A, Hildebrandt U, Pistorius G, Lindemann W, Menger M D. Laparoskopische 2-Etagenfusion der lumbalen Wirbelsäule mit Bagby-and-Kuslich (BAK)-Implantaten. Chirurg. 1996; 67 348-350
- 38 Raab M, Günther M, Godehardt E, Junginger T h. Tierexperimentelle Untersuchungen zum Nahtmaterial und zur Nahttechnik am Magen. Langenbecks Arch Chir. 1985; 365 267-277
- 39 McAdams A J, Meikle A G, Taylor J O. One layer or two layer colonic anastomoses?. Am J Surg. 1970; 120 546-550
- 40 Everett W G. A comparison of one layer and two layer techniques for colorectal anastomosis. Br J Surg. 1975; 62 135-140
- 41 Reichel K, Nagel R. Erfahrungen und Komplikationen bei der zwei- und einreihigen Enteroanastomose. Langenbecks Arch klin Chir. 1969; 323 362-373
- 42 Langer S, Pesendorfer H, Breining H, Cen M. Klinische und tierexperimentelle Studien zur Anastomosentechnik in der Darmchirurgie. Langenbecks Arch Chir. 1974; 335 309-320
- 43 Gill W, Fraser J, Carter D C, Hill R. Everted intestinal anastomosis. Surg Gynecol Obstet. 1969; 128 1297-1303
- 44 Hell K. 100 konsekutive Kolonresektionen mittels modifizierter einreihiger Naht. Helv Chir Acta. 1981; 48 833-837
- 45 Matheson N A, Irving A D. Single layer anastomosis after rectosigmoid resection. Br J Surg. 1975; 62 239-242
- 46 Peters Jr H E, Stanten A. Aseptic single layer anastomosis of the bowel. A review of one hundred seventy-five cases. Am J Surg. 1971; 122 159-163
- 47 Bennett R R, Zydeck F A. A comparison of single layer suture patterns for intestinal anastomosis. J Am Vet Med Assoc. 1970; 157 2075-2080
- 48 Jiborn H, Ahonen J, Zederfeldt B. Healing of experimental colonic anastomoses: the effect of suture technic on collagen concentration in the colonic wall. Am J Surg. 1978; 135 333-340
- 49 Jonsson T h, Högström H, Zederfeldt B. Effect of interrupted and continuous suturing on intestinal wound margin strength in rats. Eur Surg Res. 1993; 25 169-173
- 50 Olsen G B, Letwin E, Williams H TG. Clinical experience with the use of a single-layer intestinal anastomosis. Can J Surg. 1968; 11 97-100
- 51 John S, Fleischer F, Häring R. The enteroanastomosis: a micro-angiographic study of anastomotic healing. Chir Gastroent. 1976; 10 165-173
- 52 Shandall A, Lowndes R, Young H L. Colonic anastomotic healing and oxygen tension. Br J Surg. 1985; 72 606-609
- 53 Jiborn H, Ahonen J, Lindell B, Zederfeldt B. Cardiac output distribution after left colonic anastomosis in the rat. Eur Surg Res. 1979; 11 134-144
- 54 Schäfer K, Göller M, Stanka P, Ernst R, Zumtobel V. Revaskularisation von Kolonanastomosen. Langenbecks Arch Chir. 1991; 376 163-171
- 55 Bailey H R, La Voo J W, Max E, Smith K W, Butts D R, Hampton J M. Single-layer polypropylene colorectal anastomosis. Experience with 100 cases. Dis Colon Rectum. 1984; 27 19-23
- 56 Harder F, Kull C h. Fortlaufende einreihige Darmanastomose. Chirurg. 1987; 58 269-273
-
57 Vogelbach P, Harder F.
Die Technik der Dickdarmanastomosen - die fortlaufende einreihige Kolonanastomose . In: Thiede A, Lünstedt B (Hrsg.) Standards in der Viszerosynthese. Springer Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest; 1994: S. 39-45 - 58 Wayand W, Rieger R, Umlauft M. Ein- oder zweireihig? Eine kontrollierte prospektive Studie zum Vergleich zweier Nahttechniken bei gastrointestinalen Anastomosen. Chirurg. 1984; 55 650-652
- 59 Zoedler T h, Becker H, Röher H D. Die fortlaufende einreihige Anastomose als Standardverfahren im Gastrointestinaltrakt. Chirurg. 1995; 66 50-53
- 60 Ellison G W, Jokinen M P, Park R D. End-to-end approximating intestinal anastomosis in the dog: a comparative fluorescein dye, angiographic and histopathologic evaluation. J Am Anim Hosp Assoc. 1982; 18 729-736
- 61 Houdart R, Lavergne A, Galian A, Hautefeuille P. Evolution anatomo-pathologique des anastomoses digestives bord à bord en un plan. Etude de 210 anastomoses coliques chez le rat du 2e au 180e jour. Gastroenterol Clin Biol. 1983; 7 465-473
- 62 Houdart R, Lavergne A, Valleur P, Villet R, Hautefeuille P. Vascular evolution of single-layer end-on colonic anastomosis. Dis Colon Rectum. 1985; 28 475-480
- 63 Jansen A, Becker A E, Brummelkamp W H, Keeman J N, Klopper P J. The importance of the apposition of the submucosal intestinal layers for primary wound healing of intestinal anastomosis. Surg Gynecol Obstet. 1981; 152 51-58
- 64 Lamesch A, Dociu N. Die mikrochirurgische Darmnaht: Untersuchungen am Rattendarm. Z Kinderchir. 1977; 21 263-274
- 65 Schäfer K, Loeweneck H, Stanka H, Ernst R, Zumtobel V. Mikrozirkulationsstörungen bei Colonanastomosen und ihre Bedeutung für die Pathogenese der Nahtinsuffizienz. Langenbecks Arch Chir. 1990; 375 24-32
- 66 Carter D C, Jenkins D HR, Whitfield H N. Omental reinforcement of intestinal anastomoses. An experimental study in the rabbit. Br J Surg. 1972; 59 129-133
- 67 Getzen L C, Roe R D, Holloway C K. Comparative study of intestinal anastomotic healing in inverted and everted closures. Surg Gynecol Obstet. 1966; 123 1219-1227
- 68 Herzog B. Die Darmnaht. Eine tierexperimentelle Studie und Erfahrungen mit einer eigenen Nahttechnik. Aktuelle Probleme in der Chirurgie. Bd. 20 Huber Bern Stuttgart Wien; 1974
- 69 Ravitch M M, Canalis F, Weinshelbaum A, McCormick J. Studies in intestinal healing: III. Observations on everting intestinal anastomoses. Ann Surg. 1967; 166 670-680
- 70 Polglase A L, Hughes E SR, McDermott F T, Burke F R. A comparison of end-to-end staple and suture colorectal anastomosis in the dog. Surg Gynecol Obstet. 1981; 152 792-796
- 71 Chowcat N L, Savage F J, Hembry R M, Boulos P B. Role of collagenase in colonic anastomoses: a reappraisal. Br J Surg. 1988; 75 330-334
- 72 Healey Jr J E, Mc Bride C M, Gallager H S. Is serosa-to-serosa approximation necessary in intestinal anastomosis?. Surg Forum. 1964; 15 297-299
- 73 Hertzler J H, Tuttle W M. Experimental method for an everting end-to-end anastomosis in the gastrointestinal tract. Arch Surg. 1952; 65 398-405
- 74 Hell K, Allgöwer M. Die Colonresektionen. Springer Berlin Heidelberg New York; 1976
- 75 Waninger J, Kauffmann G, Schmidt J, Gorenflo M. Mikroangiographische Befunde experimenteller Darmanastomosen. Fortschr Röntgenstr. 198; 7147 87-91
- 76 Wilker D, Sklarek J, Waldner H, Posel P. Nahtfreie Anastomosen an der Ratte, am Kaninchen und am Schwein. Langenbecks Arch Chir. 1988; 373 91-96
- 77 Ravitch M M, Ong T H, Gazzola L. A new, precise, and rapid technique of intestinal resection and anastomosis with staples. Surg Gynecol Obstet. 1974; 139 6-10
- 78 Hansen H, Sommer H J, Eichelkraut W. Die Durchblutung handgenähter und geklammerter Colonanastomosen. Langenbecks Arch Chir. 1987; 370 141-151
- 79 Karppinen V, Myllärniemi H. The vascular supply of healing wound. Acta Path Microbiol Scand. 1967; 71 59-67
- 80 Abramowitz H B, McAlister W H. A comparative study of small-bowel anastomoses by angiography and microangiography. Surgery. 1969; 66 564-569
- 81 Amosov N M, Berezovsky K K. Pulmonary resection with mechanical suture. J Thorac Cardiovasc Surg. 1961; 41 325-335
- 82 Ballantyne G H, Burke J B, Rogers G, Lampert E G, Boccia J. Accelerated wound healing with stapled enteric suture lines. Ann Surg. 1985; 201 360-364
- 83 Gritsman J J. Mechanical suture by soviet appartus in gastric resection: use in 4000 operations. Surgery. 1966; 59 663-669
- 84 Ravitch M M, Rivarola A, Grov J V. Rapid creation of gastric pouches with the use of an automatic stapling instrument?. J Surg Res. 1966; 6 64-65
- 85 Schumpelick V, Braun J. Rektumresektion mit coloanaler Anastomose. Ergebnisse der Kontinenz und Radikalität. Chirurg. 1991; 62 25-31
- 86 Smith D E, Karish A F, Chapman J P, Takaro T. Healing of the bronchial stump after pulmonary resection. J Thorac Cardiovasc Surg. 1963; 46 548-556
- 87 Greenstein A, Rogers P, Moss G. Doubled fourth-day colorectal anastomotic strength with complete retention of intestinal mature wound collagen and accelerated deposition following immediate full enteral nutrition. Surg Forum. 1978; 29 78-81
- 88 Scott R N, Farac R P, Goodman D G, Militano T C, Geelhoed G W, Chretlem P B. The role of inflammation in bronchial stump healing. Ann Surg. 1975; 181 381-385
- 89 Ballantyne G H. The experimental basis of intestinal suturing. Effect of surgical technique, inflammation, and infection on enteric wound healing. Dis Colon Rectum. 1984; 27 61-71
- 90 Sacks C L. Mechanical aspects of hemostasis with surgical stapling instruments. Ann NY Acad Sci. 1964; 115 414-417
- 91 Hess J L, Mc Curnin D M, Riley M G, Koehler K J. Pilot study for comparison of chromic catgut suture and mechanically applied staples in enteroanastomosis. J Am Anim Hosp Assoc. 1981; 17 409-414
- 92 Chapuis P H, Pheils M T, Dunn D, Bokey E L, Newland R C, Colquhoun K. Mortality, morbidity and survival after colectomy for colon cancer. Aust N Z J Surg. 1983; 53 223-228
-
93 Cohn I, Nance F C.
Intestinal antisepsis and peritonitis from perforation . In: Sabiston DC (ed.) Textbook of Surgery. 12th Ed Saunders Philadelphia; 1981: pp. 1073-1076 - 94 Steichen F M. Entwicklung der Maschinennaht und Vergleich mit der manuellen Naht in der Chirurgie. Langenbecks Arch Chir. 1987; 372 79-84
- 95 Beart jr R W, Kelly K A. Randomized prospective evaluation of the EEA stapler for colorectal anastomoses. Am J Surg. 1981; 141 43-147
- 96 Dziki A J, Duncan M D, Harmon J W, Saini M, Malthaner R A, Trad K S, Fernicola M T, Hakki F, Ugarte R M. Advantages of handsewn over stapled bowel anastomosis. Dis Colon Rectum. 1991; 34 442-448
- 97 Penninckx F M, Kerremans R P, Geboes K J. The healing of single- and double-row stapled circular anastomoses. Dis Colon Rectum. 1984; 27 714-719
- 98 Scheele J, Groitl H, Pesch H -J. Auto-Suture oder Handnaht? Tierexperimentelle Untersuchungen zum Einfluß der Anastomosentechnik auf die Wundheilung am Verdauungstrakt am Beispiel des Hundekolons. Coloproctology. 1984; 6 65-76
- 99 Kozol R A, Mulligan M, Downes R J, Forouhar F A, Kreutzer D L. Early colonic anastomotic edema. Evaluation of stapled vs hand-sewn anastomoses. Dis Colon Rectum. 1988; 31 503-506
- 100 Templeton J L, McKelvey S TD. Low colorectal anastomoses. An experimental assessment of two sutured and two stapled techniques. Dis Colon Rectum. 1985; 28 38-41
- 101 Bubrick M P, Lundeen J W, Hitchcock C R. A comparative radiographic study of low anterior colon anastomoses in dogs. Surgery. 1981; 89 454-459
- 102 Dunn D H, Robbins P, Decanini C, Goldberg S, Delaney J P. A comparison of stapled and hand-sewn colonic anastomoses. Dis Colon Rectum. 1978; 21 636-639
- 103 Koruda M J, Rollandelli R H. Experimental studies on healing of colonic anastomoses. J Surg Res. 1990; 48 504-515
- 104 Berman S, Hashizume M, Yang Y, DuPree J, Matsumoto T. Intraoperative hemostasis and wound healing in intestinal anastomoses using the ILA stapling device. Am J Surg. 1988; 155 520-525
- 105 Lünstedt B, Debus S, Thiede A. Anastomosenheilung bei verschiedenen Nahtverfahren im Gastrointestinaltrakt. Physiologie, experimentelle und klinische Ergebnisse. Zentralbl Chir. 1993; 118 1-7
- 106 Smith C R, Cokelet G R, Adams J T, Schwartz S I. Vascularity of gastrointestinal staple lines demonstrated with silicone rubber injection. Am J Surg. 1981; 142 563-566
- 107 Tuchmann A, Dinstl K, Strasser K, Armbruster C. Stapling devices in gastrointestinal surgery. Int Surg. 1985; 70 23-27
- 108 Wheeless jr C R, Smith J J. A comparison of the flow of jodine 125 through three different intestinal anastomoses: standard, gambee, and stapler. Obstet Gynecol. 1983; 62 513-518
- 109 Shikata J, Shida T. Experimental studies by the resin-casting method on the vascular structure of the colon following stapler anastomoses. Dis Colon Rectum. 1985; 28 341-346
- 110 Allendorf J DF, Bessler M, Kayton M L, Whelan R L, Treat M R, Nowygrod R. Tumor growth after laparotomy or laparoscopy. A preliminary study. Surg Enodosc. 1995; 9 49-52
- 111 Allgöwer M, Hasse J, Herzog B. Colonresektionen. Chirurg. 1971; 42 1-10
- 112 Böttger G. Verhütung und Behandlung von Komplikationen in der Colonchirurgie. Chirurg. 1971; 42 10-16
- 113 Deucher F, Blessing H. Resultate der abdominalen und transanalen sphinctererhaltenden Eingriffe beim Rektosigmoidkarzinom. Schweiz Med Wschr. 1973; 103 769-775
- 114 Jiborn H, Ahonen J, Zederfeldt B. Healing of experimental colonic anastomoses. I. Bursting strength of the colon after left colon resection and anastomosis. Am J Surg. 1978; 136 587-594
- 115 Bary S. von .Klinische und experimentelle Untersuchungen zur Wundheilung des Dickdarmes unter besonderer Berücksichtigung der gewebeständigen Fibrinolyse und Kollagenolyse. Habilitationsschrift Ludwig-Maximilians-Universität München; 1979
- 116 Chlumsky V. Experimentelle Untersuchungen über die verschiedenen Methoden der Darmvereinigung. Bruns Beitr Klin Chir. 1899; 25 539-600
- 117 Waninger J, Kauffmann G W, Shah I A, Farthmann E H. Influence of the distance between interrupted sutures and the tension of sutures on the healing of experimental colonic anastomoses. Am J Surg. 1992; 163 319-323
- 118 Ehrlich H P. Regulation der Wundheilung aus der Sicht des Bindegewebes. Chirurg. 1995; 66 165-173
- 119 Jonsson T h, Högström H. Diathermy-induced inflammation does not affect suture holding capacity of intestinal anastomoses. Eur Surg Res. 1991; 23 235-239
- 120 Denecke H, Wirsching R. Colorectale Anastomosen. Chirurg. 1984; 55 638-644
- 121 Fielding L P, Stewart-Brown S, Blesovsky L, Kearney G. Anastomostic integrity after operations for large-bowel cancer: a multicentre study. Br Med J. 1980; 281 411-414
- 122 McArdle C S, Hole D. Impact of variability among surgeons on postoperative morbidity and mortality and ultimate survival. Br Med J. 1991; 302 1501-1505
- 123 Heughan C h, Grislis G, Hunt T K. The effect of anaemia on wound healing. Ann Surg. 1974; 179 163-167
- 124 Schrock T R, Deveney C W, Dunphy J E. Factors contributing to leakage of colonic anastomoses. Ann Surg. 1973; 177 513-518
- 125 Stelzner F. Operationstechnisch bedingte Mißerfolge bei der Behandlung des Kolon- und Rektumkarzinoms. Zentralbl Chir. 1977; 102 1559-1563
-
126 Lünstedt B, Debus S, Thiede A. Standards in der Viszerosynthese.
Anastomosenheilung bei verschiedenen Nahtverfahren im Gastrointestinaltrakt - Physiologie, experimentelle und klinische Ergebnisse. In: Thiede A, Lünstedt B (Hrsg) Springer Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest; 1994: S. 3-13 - 127 Stephens F O, Hunt T K. Effect of changes in inspired oxygen and carbon dioxide tensions on wound tensile strength: an experimental study. Ann Surg. 1971; 173 515-519
- 128 Udenfriend S. Formation of hydroxyproline in collagen. Science. 1966; 152 1335-1340
- 129 Kivisaari J, Vihersaari T, Renvall S, Niinikoski J. Energy metabolism of experimental wounds at various oxygen environments. Ann Surg. 1975; 181 823-828
-
130 Silver I A.
Local and systemic factors which affect the proliferation of fibroblasts . In: Kulonen E, Pikkarainen J (Eds.) Biology of Fibroblast. Academic Press London; 1973: pp. 507-519 - 131 McLachlin A D, Denton D W. Omental protection of intestinal anastomoses. Am J Surg. 1973; 125 134-140
- 132 Cartier R, Brunette I, Hashimoto K, Bourne W M, Schaff H V. Angiogenetic factor: a possible mechanism for neovascularization produced by omental pedicles. J Thorac Cardiovasc Surg. 1990; 99 264-268
- 133 Adams W, Ctercteko G, Bilous M. Effect of an omental wrap on the healing and vascularity of compromised intestinal anastomoses. Dis Colon Rectum. 1992; 35 731-738
- 134 Goldsmith H S. Protection of low rectal anastomosis with intact omentum. Surg Gynecol Obstet. 1977; 144 584-586
- 135 Lanter B, Mason R A. Use of omental pedicle graft to protect low anterior colonic anastomosis. Dis Colon Rectum. 1979; 22 448-451
- 136 Everett W G. Suture materials in general surgery. Progr Surg. 1970; 8 14-37
- 137 Howes E L, Sooy J W, Harvey S C. The healing of wounds as determined by their tensile strength. JAMA. 1929; 92 42-45
- 138 Khoury G A, Waxman B P. Large bowel anastomoses. I. The healing process and sutured anastomoses. A review. Br J Surg. 1983; 70 61-63
- 139 Kracht M, Hay J M, Fagniez P L, Fingerhut A. Ileocolonic anastomosis after right hemicolectomy for carcinoma: stapled or hand-sewn? A prospective, multicenter, randomized trial. Int J Colorectal Dis. 1993; 8 29-33
- 140 Nöthiger F, Ziegler W, Finger J, Kaufmann R. Nahtmaterial in der Darmanastomose. Helv Chir Acta. 1980; 14 1-42
- 141 Winkle jr van W, Hastings J C. Considerations in the choice of suture material for various tissues. Surg Gynecol Obstet. 1972; 135 113-126
- 142 Fontaine C J, Dudley H AF. Assessment of suture materials for intestinal use by an extramucosal inplant technique and a quantitative histological evaluation. Br J Surg. 1978; 65 288-290
- 143 Lord M G, Broughton A C, Williams H TG. A morphologic study on the effect of suturing the submucosa of the large intestine. Surg Gynecol Obstet. 1978; 146 211-216
- 144 Nockemann P F. Die chirurgische Naht. Thieme 3. Auflage Stuttgart New York; 1980
- 145 Edlich R F, Panek P H, Rodenheaver G T, Turnbull V G, Kurtz L D, Edgerton M T. Physical and chemical configuration of sutures in the development of surgical infection. Ann Surg. 1973; 177 679-688
- 146 Herrmann J B. Changes in the tensile strength and knot security of surgical sutures in vivo. Arch Surg. 1973; 106 707-710
- 147 Postlethwait R W. Long-term comparative study of nonabsorbable sutures. Ann Surg. 1970; 171 892-
- 148 Postlethwait R W. Polyglycolic acid surgical suture. Arch Surg. 1970; 101 489-494
- 149 Foster M E, Brennan S S, Morgan A, Leaper D J. Colonic ischaemia and anastomotic healing. Eur Surg Res. 1985; 17 133-139
- 150 Magilligan jr D J, De Weese J A. Knot security and synthetic suture materials. Am J Surg. 1974; 127 355-358
- 151 Trimpi H D, Khubchandani I T, Sheets J A, Stasik J J. Advances in intestinal anastomosis: Experimental study and an analysis of 984 patients. Dis Colon Rectum. 1977; 20 107-117
- 152 Hudemann H. Chirurgisches Nahtmaterial. Fischer Jena; 1959
- 153 Deveney K E, Way L W. Effect of different absorbable sutures on healing of gastrointestinal anastomoses. Am J Surg. 1977; 133 86-94
- 154 Durdey P, Bucknall T E. Assessment of sutures for use in colonic surgery: An experimental study. J R Soc Med. 1984; 77 472-477
- 155 Hastings J C, van Winkle W, Barker E, Hines D, Nichols W. Effect of suture materials on healing wounds of the stomach and the colon. Surg Gynecol Obstet. 1975; 140 701-707
-
156 Nöthiger F.
Vergleichende Untersuchungen zur Wertigkeit des Nahtmaterials bei der Dickdarmanastomose . In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S. 122-127 - 157 Riddick D H, De Grazia C T, Maenza R M. Comparison of polyglactic and polyglycolic acid sutures in reproductive tissue. Fertility and Sterility. 1977; 28 1220-1225
- 158 Lünstedt B, Thiede A. Polydioxanon (PDS) - ein neues monofiles, synthetisches, absorbierbares Nahtmaterial. Zugfestigkeitsuntersuchungen in einem klinisch kontrollierten Versuch am Dickdarm des Menschen und physikalische Parameter im in-vitro-Test. Chirurg. 1983; 54 103-107
- 159 Stephens F O, Hunt T K, Dunphy J E. Study of traditional methods of care on the tensile strength of skin wounds in rats. Am J Surg. 1971; 122 78-80
- 160 Farella S, Cola B; Franchini A. Endoskopische Beurteilung der verschiedenen Heilungsstadien kolorektaler Anastomosen. Colo-proctology. 1984; 2 86-90
- 161 Entner M, Heimberger H. One row anastomosis in colonic operations with antibiotic prophylaxis. Surg Gynecol Obstet. 1985; 161 136-138
-
162 Thiede A.
Biologische Wertigkeit der Nahtmaterialien . In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S.238-252 - 163 Letwin E R. Evaluation of polyglycolic acid sutures in colonic anastomoses. Can J Surg. 1975; 18 30-33
- 164 Kapadia C R, Mann J B, McGeehan D, Jose Biglin J E, Waxman B P, Dudley H AF. Behaviour of synthetic absorbable sutures with and without synergistic enteric infection. Eur Surg Res. 1983; 15 67-72
- 165 Cowley L L. Wire sutures: braided or monofilament?. Am J Surg. 1967; 113 472-474
- 166 Katz S, Izhar M, Mirelman D. Bacterial adherence to surgical sutures. A possible factor in the suture induced infection. Ann Surg. 1981; 194 35-41
- 167 Mc Geehan D, Hunt D, Chaudhuri A, Rutter P. An experimental study of the relationship between synergistic wound sepsis and suture materials. Br J Surg. 1980; 67 636-638
- 168 Blomstedt R, Österberg B. Fluid absorption and capillarity of suture materials. Acta Chir Scand. 1977; 143 67-70
-
169 Dudley H AF, Kapadia C R.
Sutures and infection: studies of conventional materials and new synthetic absorbables. In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S. 34-38 - 170 Eichfuss H P. Der Bauchchirurg und sein Nahtmaterial. Med Welt. 1976; 27 562-565
- 171 Schütze U, Henningsen B, Daum R, Seufert R. Polyglycolic acid sutures for intestinal anastomoses in paediatric surgery. Experimental and first clinical findings. Z Kinderchir. 1978; 25 76-80
- 172 Blomstedt B, Österberg B, Bergstrand A. Suture material and bacterial transport. An experimental study. Acta Chir Scand. 1977; 143 71-73
- 173 Thiede A, Jostarndt L, Lünstedt B, Sonntag H G. Kontrollierte experimentelle histologische und mikrobiologische Untersuchungen zur Hemmwirkung von Polyglycolsäurefäden bei Infektionen. Chirurg. 1980; 51 35-38
-
174 Thiede A, Jostarndt L, Lünstedt B, Sonntag H G.
Zum Verhalten kontaminierter absorbierbarer Nahtmaterialien in vivo . In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S 55-63 - 175 Arbogast R, Gay B, Höcht B. Der Einfluß des Nahtmaterials auf die mechanische Belastbarkeit von Darmanastomosen. Chirurg. 1978; 49 640-644
- 176 Kratzer G L. Intestinal anastomosis and abdominal wound closure using monofilament prolene polypropylene suture: report of fifty cases. Dis Colon Rectum 1978 21: 342-345
- 177 Munday C, McGinn F P. A comparison of polyglycolic acid and catgut sutures in rat colonic anastomoses. Br J Surg. 1976; 63 870-872
- 178 Hawley P R. Causes and prevention of colonic anastomotic breakdown. Dis Colon Rectum. 1973; 16 272-277
- 179 Hesp F LEM, Hendriks T, Lubbers E JC. de Boer HHM. Wound healing in the intestinal wall. A comparison between experimental ileal and colonic anastomoses. Dis Colon Rectum. 1984; 27 99-104
- 180 Irvin T T, Hunt T K. The effect of trauma on colonic healing. Br J Surg. 1974; 61 430-436
- 181 Le Veen H H, Wapnick S, Falk G, Olivas O, Bhat D, Gaurdre M, Patel M. Effects of prophylactic antibiotics on colonic healing. Am J Surg. 1976; 131 47-53
- 182 Schardey H M, Kamps T, Rau H G, Gatermann S, Baretton G, Schildberg F W. Bacteria: A major factor of anastomotic insufficiency following gastrectomy. Antimicrob Agents Chemother. 1994; 38 2564-2567
- 183 Cohn I. jr . Intestinal antisepsis. Surg Gynecol Obstet. 1970; 130 1006-1014
- 184 Högström H, Jiborn H, Zederfeldt B, Haglund U. Influence of intraperitoneal Escherichia coli with septicemia on the healing of colonic anastomoses and skin wounds. Eur Surg Res. 1985; 17 128-132
- 185 Lee J T, Ahrenholz D H, Nelson R D, Simmons R L. Mechanisms of the adjuvant effect of hemoglobin in experimental peritonitis. V. The significance of the coordinated iron component. Surgery. 1979; 86 41-48
- 186 Mellish R WP, Ty T C, Keller D J. A study of intestinal healing. J Pediatr Surg. 1968; 3 286-291
- 187 Canalis F, Ravitch M M. Study of healing of inverting and everting intestinal anastomoses. Surg Gynecol Obstet. 1968; 126 109-114
- 188 Rusca J A, Bornside G H, Cohn I. Everting versus inverting gastrointestinal anastomoses: bacterial leakage and anastomotic disruption. Ann Surg. 1969; 169 727-735
- 189 Abramowitz H B, Butcher H R. Everting and inverting intestinal anastomosis: an experimental study of comparative safety. Am J Surg. 1971; 121 52-53
- 190 Hawley P R, Faulk W P, Hunt T K, Dunphy J E. Collagenase activity in the gastro-intestinal tract. Br J Surg. 1970; 57 896-900
- 191 Hesp F LEM, Hendriks T, Lubbers E JC, De Boer H HM. Wound healing in the intestinal wall. Effects of infection on experimental ileal and colonic anastomoses. Dis Colon Rectum. 1984; 27 462-467
- 192 Irvin T T, Hunt T K. Pathogenesis and prevention of disruption of colonic anastomoses in traumatized rats. Br J Surg. 1974; 61 437-439
- 193 Irvin T T. Collagen metabolism in infected colonic anastomoses. Surg Gynecol Obstet. 1976; 143 220-224
- 194 Morgenstern L, Yamakawa T, Ben-Shoshan M, Lippman H. Anastomotic leakage after low colonic anastomosis. Clinical and experimental aspects. Am J Surg. 1972; 123 104-109
- 195 Yamakawa T, Patin C S, Sobel S, Morgenstern L. Healing of colonic anastomoses following resection for experimental „diverticulitis”. Arch Surg. 1971; 103 17-20
- 196 Högström H, Haglund U. Neutropenia prevents decrease in strength of rat intestinal anastomosis: Partial effect of oxygen free radical scavengers and allopurinol. Surgery. 1986; 99 716-720
-
197 Ohlsson K.
Polymorphonuclear leukocyte collagenase . In: Woolley D, Evanson J (Eds.) Collagenase in normal and pathological connective tissue. Wiley Chichester; 1980: pp. 209-222 - 198 Shandall A A, Williams G T, Hallett M B, Young H L. Colonic healing: a role for polymorphonuclear leucocytes and oxygen radical production. Br J Surg. 1986; 73 225-228
-
199 Starkey P H.
Elastase and cathepsin G. In: Barrett AJ (Ed.) The serine proteinases of human neutrophil leucocytes and spleen. Elsevier Amsterdam; 1977: pp. 57-89 - 200 Cronin K, Jackson D S, Dunphy J E. Changing bursting strength and collagen content of the healing colon. Surg Gynecol Obstet. 1968; 126 747-753
- 201 Jönsson K, Jiborn H, Zederfeldt B. Breaking strength of small intestinal anastomoses. Am J Surg. 1983; 145 800-803
- 202 Foster M E, Johnson C D, Billings P J, Davies P W, Leaper D J. Intraoperative antegrade lavage and anastomotic healing in acute colonic obstruction. Dis Colon Rectum. 1986; 29 255-259
- 203 Nagelschmidt M, Becker D, Stuttmann R, Engelhardt G H. Fibronektin-Mangel verzögert die Wundheilung bei Ratten. Langenbecks Arch (Chir Forum) 1986: 33-37
- 204 Nagelschmidt M, Becker D, Bönninghoff N, Engelhardt G H. The effect of fibronectin therapy and fibronectin deficiency on healing of rat burns and excision wounds. Res Exp Med. 1987; 187 217-223
- 205 Metzger Z, Hoffeld J T, Oppenheim J J. Suppression of fibroblast proliferation by activated macrophages: Involvement of H2O2 and a non-prostaglandin E product of the cyclooxygenase pathway. Cell Immunol. 1986; 100 501-514
- 206 Phan S M, McGarry B M, Loeffler K M, Kunkel S L. Regulation of macrophage-derived fibroblast growth factor release by arachidonate metabolites. J Leukoc Biol. 1987; 42 106-113
- 207 Sugarman B J, Aggarwal B B, Hass P E, Figari I S, Palladino jr M A, Shepard H M. Recombinant human tumor necrosis factor-α: Effects on proliferation of normal and transformed cells in vitro. Science. 1985; 230 943-945
- 208 Sugarman B J, Lewis G D, Eessalu T E, Aggarwal B B, Shepard H M. Effects of growth factors on the antiproliferative activity of tumor necrosis factors. Cancer Res. 1987; 47 780-786
- 209 Ahrendt G M, Gardner K, Barbul A. Loss of colonic structural collagen impairs healing during intra-abdominal sepsis. Arch Surg. 1994; 129 1179-1183
- 210 Högström H, Bondeson L, Haglund U. Neutrophil-induced decrease in wound margin strength after intestinal anastomosis: influence on collagen and mechanisms of granulocyte action. Eur Surg Res. 1988; 20 260-266
- 211 Jonsson T h, Högström H. Neutrophil-dependent decrease in early wound margin strength. Arch Surg. 1991; 126 1423-1426
- 212 Nahai F, Lamb J M, Havican R G, Stone H H. Factors involved in disruption of intestinal anastomoses. Am Surg. 1977; 43 45-51
- 213 Faß J. Die Wundheilungsstörung in der Chirurgie des colo-rectalen Carcinoms. Eine multifaktorielle Computeranalyse. Langenbecks Arch Chir. 1985; 367 63-73
- 214 Giercksky K E, Danielsen S, Garberg O, Gruener O P, Holter O, Johnson J A, Nygaard K, Ofstad E, Stadaas J, Viddal K O. A single dose tinidazole and doxycycline prophylaxis in elective surgery of colon and rectum. A prospective controlled clinical multicenter study. Ann Surg. 1982; 195 227-231
- 215 Görtz G, Häring R, Raetzel G, Rodloff A. Cephalosporine zur Infektionsprophylaxe im Rahmen der Kolonchirurgie. FAC Fortschritte d. antimikrobiellen und antineoplastischen Chemotherapie. 1982; 1 237-245
- 216 Hepp J, Käufer C. Infektionsverhütung in der Dickdarm-Chirurgie durch Cefoxitin und orthograde Darmspülung. Krankenhausarzt. 1982; 55 885-891
- 217 Hildebrandt J, Diettrich H. Moderne mechanisch-antibiotische Vorbereitung bei kolorektalen Operationen. Ergebnisse einer prospektiven Studie. Zentralbl Chir. 1985; 110 93-97
- 218 Jostarndt L, Thiede A, Sonntag H G, Hamelmann H. Die systemische Antibioticumprophylaxe in der elektiven Colonchirurgie. Ergebnisse einer kontrollierten Studie. Chirurg. 1981; 52 398-402
- 219 Kusche J, Stahlknecht C D. Antibiotikaprophylaxe bei colorectalen Operationen. Gibt es ein Mittel der Wahl?. Chirurg. 1981; 52 577-585
- 220 Lohr J, Wagner P K, Rothmund M. Perioperative Antibiotikaprophylaxe (Einmal- oder Mehrfachgabe) bei elektiven colorectalen Eingriffen. Chirurg. 1984; 55 512-514
- 221 Cohen S R, Cornell C N, Collins M H, Sell J E, Blanc W A, Altman R P. Healing of ischemic colonic anastomoses in the rat: role of antibiotic preparation. Surgery. 1985; 97 443-446
- 222 Schardey H M, Kamps T, Rau H G, Baretton G, Gatermann S, Exner H, Schildberg F W. Can oesophago-intestinal anastomotic leakage develop in the complete absence of bacteria? A comparison of normal and germ-free rats. Int J Surg Science. 1997; 4 9-13
- 223 Schardey H M, Joosten U, Finke U, Staubach K H, Schauer R, Heiss A, Kooistra A, Rau H G, Nibler R, Lüdeling S, Unertl K. Ruckdeschel G, Exner, H, Schildberg FW. The prevention of anastomotic leakage after total gastrectomy with local decontamination. Ann Surg. 1997; 225 172-180
- 224 Schardey H M, Krämling H J, Cramer C, Kusenack U, Hadersbeck J, Schildberg F W. Risikofaktoren und pathogene Mikroorganismen bei Patienten mit insuffizienter Ösophago-Jejunostomie nach Gastrektomie. Zentralblatt Chir. 1998; 123 46-52
- 225 Curley S A, Allison D C, Smith D E, Doberneck R C. Analysis of techniques and results in 347 consecutive colon anastomoses. Am J Surg. 1988; 155 597-601
- 226 Rolandelli R H, Koruda M J, Settle R G, Rombeau J L. The effect of enteral feedings supplemented with pectin on the healing of colonic anastomoses in the rat. Surgery. 1986; 99 703-707
- 227 Rolandelli R H, Koruda M J, Settle R G, Rombeau J L. Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomosis in the rat. Surgery. 1986; 100 198-204
- 228 Blomquist P, Jiborn H, Zederfeldt B. Effect of diverting colostomy on collagen metabolism in the colonic wall. Studies in the rat. Am J Surg. 1985; 149 330-333
- 229 Blomquist P, Jiborn H, Zederfeldt B. Effect of diverting colostomy on breaking strength of anastomoses after resection of the left side of the colon. Studies in the rat. Am J Surg. 1985; 149 712-715
- 230 Udén P, Blomquist P, Jiborn H, Zederfeldt B. Influence of proximal colostomy on the healing of a left colon anastomosis: an experimental study in the rat. Br J Surg. 1988; 75 325-329
- 231 Wara P, Sorensen K, Berg V. Proximal fecal diversion: review of ten years’ experience. Dis Colon Rectum. 1981; 24 114-119
- 232 Blomquist P, Ahonen J, Jiborn H, Zederfeldt B. The effect of relative bowel rest on healing of colonic anastomoses. Collagen synthesis and content in the colonic wall after left colon resection and anastomosis in the rat. Acta Chir Scand. 1984; 150 677-681
- 233 Blomquist P, Jiborn H, Zederfeldt B. The effect of relative bowel rest on healing of colonic anastomoses. Breaking strength and collagen in the colonic wall following left colon resection and anastomosis in the rat. Acta Chir Scand. 1984; 150 671-675
- 234 Högström H, Haglund U, Zederfeldt B. Beneficial effect of proteinase inhibitors on early breaking strength of intestinal anastomoses. Acta Chir Scand. 1985; 151 529-532
- 235 Young H L, Wheeler M H. Results of a prospective randomized doubleblind trial of aprotinin in colonic surgery. World J Surg. 1984; 8 367-373
- 236 Hawley P R, Page Faulk W. A circulatory collagenase inhibitor. Br J Surg. 1970; 57 900-904
- 237 Högström H, Haglund U. Postoperative decrease in suture holding capacity in laparotomy wounds and anastomoses. Acta Chir Scand. 1985; 151 533-535
- 238 Jönsson K, Jiborn H, Zederfeldt B. Collagen metabolism in small intestinal anastomosis. Am J Surg. 1987; 154 288-291
- 239 Bary S v on, Kortmann H, Köpcke W. Berstungsdrücke des enterotomierten Rattencolons unter Proteinaseinhibition. Res Exp Med. 1976; 168 123-128
- 240 Delaney P, Lalor D. Enzyme inhibition in colorectal surgery. Br J Surg. 1976; 63 23-24
- 241 Young H L, Wheeler M H. Collagenase inhibition in the healing colon. J R Soc Med. 1983; 76 32-36
- 242 Virca G D, Metz G, Schnebli H P. Similarities between human and rat leukocyte elastase and cathepsin G. Eur J Biochem. 1984; 144 1-9
- 243 Fritz H, Wunderer G. Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs. Arzneim. Forschung / Drug Res. 1983; 33 479-494
- 244 Högström H, Haglund U, Zederfeldt B. Beneficial effect on intestinal anastomoses of S-2441, a synthetic kallikrein-kinin antagonist. Experimental studies in the rat. Am J Surg. 1985; 150 312-314
- 245 Ryan G B, Majno G. Acute Inflammation. Am J Pathol. 1977; 86 183-276
- 246 Högström H, Haglund U. Early decrease in suture line breaking strength. The effect of proposed collagenase inhibition. Res Exp Med. 1985; 185 451-455
- 247 Stewart R. Influence of malignant cells on the healing of colonic anastomoses: experimental observations. Proc Roy Soc Med. 1973; 66 1089-1091
- 248 Hawley P R. Cancer of the colon and rectum: Collagenase activity in patients who have rectal carcinoma. Dis Colon Rectum. 1976; 19 9-10
- 249 Albertson S, Hummel III R P, Breeden M, Greenhalgh D G. PDGF and FGF reverse the healing impairment in protein-malnourished diabetic mice. Surgery. 1993; 114 368-373
- 250 Beickert R, von Imhoff C. Nahtinsuffizienz am Dickdarm: Ist der Operateur ein Risikofaktor?. Chirurg. 1984; 55 645-649
- 251 Brennan S S, Pickford I R, Evans M, Pollock A V. Staples or sutures for colonic anastomoses. A controlled clinical trial. Br J Surg. 1982; 69 722-724
- 252 Gilmour D G, Aitkenhead A R, Hothersall A P, Mc A. Ledingham I. The effect of hypovolaemia on colonic blood flow in the dog. Br J Surg. 1980; 67 82-84
- 253 Irvin T T, Goligher J C. Aetiology of disruption of intestinal anastomoses. Br J Surg. 1973; 60 461-464
- 254 Kühlmayer R, Doberauer B. Die letale Nahtdehiszenz als Risikofaktor der Kolon-Rektumchirurgie. Wien Med Wschr. 1981; 131 395-399
- 255 Stelzner F. Vorbeugung der intraperitonealen Nahtinsuffizienz (Dünn- und Dickdarm). Langenbecks Arch Chir. 1982; 358 259-263
- 256 Wayand W, Rieger R, Umlauft M. Ein- oder zweireihig? Eine kontrollierte prospektive Studie zum Vergleich zweier Nahttechniken bei gastrointestinalen Anastomosen. Chirurg. 1984; 55 650-652
-
257 Athanasiadis S, Girona J, Gandji D, Lutfi T.
Die Bedeutung der Nahttechnik in der Darmchirurgie . In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S. 199-207 - 258 Beickert R, von Imhoff C. Nahtinsuffizienz am Dickdarm: Ist der Operateur ein Risikofaktor?. Chirurg. 1984; 55 645-649
-
259 Eichfuss H P, Knipper A.
Wundheilung am Darm bei akuter und chronischer Peritonitis . In: Häring R (Hrsg) Peritonitis. TM Bad Oeynhausen; 1979: S 154-157 - 260 Merkle P. Entero-enterale Anastomosen. Chirurg. 1984; 55 632-637
-
261 Meyer G, Lange V, Oevermann E, Schildberg F W.
Notfallchirurgie beim kolorektalen Karzinom: Risikofaktoren, onkologischer Stellenwert und therapeutische Möglichkeiten . In: Hollender LF, De Manzini N (Eds) Chirurgie d’urgence. Tome I 1990: pp 413-415 - 262 Slavin J, Nash J R, Kingsnorth A N. Effect of transforming growth factor beta and basic fibroblast growth factor on steroid-impaired healing intestinal wounds. Br J Surg. 1992; 79 69-72
- 263 Wilker D, Sklarek J, Waldner H, Izbicki J R, Siebeck M. Untersuchung zur Frühphase der Anastomosenheilung unter besonderer Berücksichtigung von Peritonitis und Ischämie. Langenbecks Arch Chir. 1988; 373 217-221
- 264 Christensen H, Oxlund H, Laurberg S. Postoperative biosynthetic human growth hormone increases the strength and collagen deposition of experimental colonic anastomoses. Int J Colorect Dis. 1991; 6 133-138
- 265 Goodman L, Stein G H. Basal and induced amounts of interleukin-6 mRNA decline progressively with age in human fibroblasts. J Biol Chem. 1994; 269 19 250-19 255
- 266 Hamon G A, Hunt T K, Spencer E M. In vivo effects of systemic insulin-like growth factor-I alone and compleated with insulin-like growth factor binding protein-3 on corticosteroid suppressed wounds. Growth Regul. 1993; 3 53-56
- 267 Kingsnorth A N, Vowles R, Nash J RG. Epidermal growth factor increases tensile strength in intestinal wounds in pigs. Br J Surg. 1990; 77 409-412
- 268 Watson R WG, Redmond H P, Mc Carthy J, Burke P E, Bouchier-Hayes D. Exposure of the peritoneal cavity to air regulates early inflammatory responses to surgery in a murine model. Br J Surg. 1995; 82 1060-1065
- 269 Hofstädter F. Pathologie der Wundheilung. Chirurg. 1995; 66 174-181
-
270 Zederfeldt B.
Anastomotic Healing. In: Eigler FW, Gross E, Vogt E (Hrsg) Die Anastomose am Gatrointestinaltrakt. TM Hameln; 1990: S 13-16 - 271 Meßmer K, Wanner K, Reulen H J. Durchblutungsverhalten abdomineller Organe nach Endotoxininjektion beim Hund. Z Ges Exp Med. 1968; 146 292-308
-
272 Leder L D.
Wundheilung und Fremdkörperreaktion . In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S226-228 - 273 Lindner J. Morphologie und Biochemie der Wundheilung. Langenbecks Arch Chir (Kongreßbericht 1982). 1982; 358 153-160
-
274 Schäfer K, Stanka H, Ernst R, Zumtobel V.
Ausdehnung und Bedeutung von Mikrozirkulationsstörungen für die Pathogenese der Nahtinsuffizienz bei Colonanastomosen . In: Eigler FW, Gross E, Vogt E (Hrsg) Die Anastomose am Gastrointestinaltrakt. TM Hameln; 1990: S 39-47 - 275 Graham M F, Drucker D EM, Diegelmann R F, Elson C O. Collagen synthesis by human intestinal smooth muscle cells in culture. Gastroenterology. 1987; 92 400-405
- 276 Peterkofsky B. Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy. Am J Clin Nutr. 1991; 54 1135S-1140S
- 277 Bark S, Rettura G, Goldman D, Seifter E, Levenson S, Demetriou A A. Effect of supplemental vitamin A on the healing of colon anastomosis. J Surg Res.. 1984; 36 470-474
- 278 Winsey K, Simon R J, Levenson S M, Seifter E, Demetriou A A. Effect of supplemental vitamin A on colon anastomotic healing in rats given preoperative irradiation. Am J Surg. 1987; 153 153-156
- 279 Daly J M, Vars H M, Dudrick S J. Effects of protein depletion on strength of colonic anastomoses. Surg Gynecol Obstet. 1972; 134 15-21
- 280 Preshaw R M, Attisha R P, Hollingsworth W J, Todd J D. Randomized sequential trial of parenteral nutrition in healing of colonic anastomoses in man. Can J Surg. 1979; 22 437-439
- 281 Rahmat A, Norman J N, Smith G. The effect of zinc deficiency on wound healing. Br J Surg. 1974; 61 271-273
- 282 Jochum M, Witte J, Schiessler H, Selbmann H K, Ruckdeschl G, Fritz H. Clotting and other plasma factors in experimental endotoxemia: inhibition of degradation by exogenous proteinase inhibitors. Eur Surg Res. 1981; 13 152-168
- 283 Müller-Berghaus G. Pathophysiology of generalized intravascular coagulation. Semin Thromb Hemost. 1977; 3 209-246
- 284 Greuer W, Hee E, Klein-Buchholz F, Marggraf G, Quadripur S, Stankovic P, Weber H G, Wilde G. Spontane periphere Proteolyse. 1. Mitteilung: Methodik und klinische Untersuchungsergebnisse. Surg Res. 1976; 26 89-103
- 285 Haverkate F, Brakman P. Fibrin plate essay. Progr Chem Fibrinol Thrombol. 1975; 1 151-162
- 286 Rotstein D, Pruett T L, Simmons R L. Fibrin in peritonitis. Ann Surg. 1986; 203 413-419
- 287 Högström H, Claeson G, Larsson-Backström C, Lundberg D, Wenngren E, Haglund U. Septic shock in the rat: Activation of plasma proteolytic systems and effects of a kallikrein inhibitor/bradykinin antagonist (S-2441). Acta Chir Scand. 1987; 153 161-164
- 288 Tagart R EB. Colorectal anastomosis: factors influencing success. J R Soc Med. 1981; 74 111-118
- 289 Scheele J, Husemann B, Pesch H J. Kolonanastomosen im Tierexperiment. Mechanische und morphologische Befunde. Z Exp Chir. 1978; 11 110-120
- 290 Lee E. The effect of obstructive jaundice on the migration of reticulo-endothelial cells and fibroblasts into early experimental granulomata. Br J Surg. 1972; 59 875-877
- 291 Than T, McGee J O’D, Sokhi G S, Patrick R S, Blumgart L H. Skin prolyl hydroxylase in patients with obstructive jaundice. Lancet. 1974; 2 807-808
PD Dr. G. Meyer
Chirurgische Klinik und Poliklinik
Klinikum Großhadern
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