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Synthesis 2001(5): 0690-0692
DOI: 10.1055/s-2001-12758
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A Novel Method for the Synthesis of N-Per(poly)fluoroalkanesulfonyl Amino Acids

Yong Xu, Shizheng Zhu*
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
Fax: +86(21)64166128; e-Mail: zhusz@pub.sioc.ac.cn;
Further Information

Publication History

Received 9 January 2001
Publication Date:
28 September 2004 (online)

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Abstract

Treatment of disilyl ketene acetals with per(poly)fluoroalkanesulfonyl azides at 0 °C in acetonitrile afforded N-sulfonyl-protected α-amino acids in good yields. The method provided a novel and convenient access to N-sulfonyl-protected α-amino acids.

Key words

amino acids - amination - disilyl ketene acetals - fluoroalkanesulfonyl azides - sulfonyl-protected

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