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Synthesis 2001(5): 0690-0692
DOI: 10.1055/s-2001-12758
DOI: 10.1055/s-2001-12758
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
A Novel Method for the Synthesis of N-Per(poly)fluoroalkanesulfonyl Amino Acids
Further Information
Received
9 January 2001
Publication Date:
28 September 2004 (online)
Publication History
Publication Date:
28 September 2004 (online)
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Abstract
Treatment of disilyl ketene acetals with per(poly)fluoroalkanesulfonyl azides at 0 °C in acetonitrile afforded N-sulfonyl-protected α-amino acids in good yields. The method provided a novel and convenient access to N-sulfonyl-protected α-amino acids.
Key words
amino acids - amination - disilyl ketene acetals - fluoroalkanesulfonyl azides - sulfonyl-protected
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