Endoscopic Mucosal Resection and Full Thickness Resection with Complete Defect Closure for Early Gastrointestinal Malignancies

Background and Study Aims: We developed a new endoscopic technique, the endoscopic full-thickness resection (EFTR) and endoscopic complete defect closure (ECDC), for the treatment of early gastrointestinal malignancies.

Patients and Methods: Two rectal and one duodenal carcinoid were treated by EFTR with ECDC and resectability, complications and pathological findings were evaluated.

Results: In all cases, the lesion was completely resected without serious complications. The histology of the specimen also confirmed complete resection of the tumor.

Conclusions: This technique has great potential for the treatment of early gastrointestinal malignancies. Preliminary results have shown that early malignant gastrointestinal lesions can be safely and completely resected by EFTR with ECDC.

References

• 1 Suzuki H. Endoscopic treatment of early cancer in Japan. Have we reached the limit?.  Endoscopy. 1998;  30 578
• 2 Ohshiba S, Ashida K, Tanaka M, et al. Curative endoscopic resection of early gastric cancer. The possibility of extending its indication (in Japanese, English abstract).  Stomach Intest. 1993;  28 1421-1426
• 3 Tada M, Shimada M, Murakami F, et al. Development of the strip-off biopsy (in Japanese, English abstract).  Gastroenterol Endosc. 1984;  26 833-839
• 4 Takekoshi T, Takagi K, Katoh Y, et al. Evaluation of endoscopic resection by double snare method for early gastric cancer (in Japanese, English abstract).  Endosc Dig. 1989;  1 163-177
• 5 Masuda K, Fujisaki J, Suzuki H, et al. Endoscopic mucosal resection using a ligating device (EMR-L) (in Japanese, English abstract).  Endosc Dig. 1993;  5 1215-1219
• 6 Okuwaki S. Experimental and clinicopathological study on endoscopic mucosal resection for early gastric cancer - aiming at safe and reliable resection (in Japanese, English abstract).  Tokyo Jikeikai Med J. 1995;  110 561-576
• 7 Suzuki H, Okuwaki S, Ikeda K, et al. Endoscopic full-thickness resection (EFTR) and waterproof defect closure (ENDC) for improvement of curability and safety in endoscopic treatment of early gastrointestinal malignancies (in Japanese, English abstract).  Prog Dig Endosc. 1998;  52 49-53