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Endoscopy 2001; 33(5): 416-420
DOI: 10.1055/s-2001-14424
Original Article

© Georg Thieme Verlag Stuttgart · New York

Is Endoscopic Balloon Dilation for Removal of Bile Duct Stones Associated with an Increased Risk for Pancreatitis or a Higher Rate of Hyperamylasemia?

J. J. G. H. M. Bergman1 , A.-M. van Berkel1 , M. J. Bruno1 , P. Fockens1 , E. A. J. Rauws1 , J. G. P. Tijssen2 , G. N. J. Tytgat1 , K. Huibregtse1
  • 1 Dept. of Gastroenterology, Academic Medical Center, University of Amsterdam, The Netherlands
  • 2 Dept. of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands
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Publikationsdatum:
31. Dezember 2001 (online)

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Background and Study Aims: We studied the rate of pancreatitis and asymptomatic hyperamylasemia after endoscopic balloon dilation (EBD) and endoscopic sphincterotomy (EST) for removal of bile duct stones.

Patients and Methods: Patients with bile duct stones of all sizes were randomly allocated to undergo EBD (8-mm dilation balloon) or EST. Pancreatitis was defined as epigastric pain combined with at least a threefold rise in serum amylase at 24 hours after the endoscopic retrograde cholangiopancreatography (ERCP). Asymptomatic hyperamylasemia was defined as a threefold rise in serum amylase without epigastric pain.

Results: There were 180 patients (67 men, 113 women; mean age 67, SD 16.2) available for analysis. Complete stone removal after a single ERCP was achieved in 82 (88 %) of 93 EBD patients and in 81 (93 %) of 87 EST patients (P = 0.38). Mechanical lithotripsy was used more frequently in the EBD group (31 % vs. 13 %, P = 0.005). Early complications occurred in 16 EBD patients (17 %) and in 19 EST patients (22 %) (P = 0.46). Pancreatitis was observed in seven patients in each group (8 %). Logistic regression identified no significant predictors for the occurrence of pancreatitis. Asymptomatic hyperamylasemia occurred in 21 EBD patients (23 %) vs seven EST patients (8 %) (P = 0.008). Logistic regression identified EBD as the only significant predictor for asymptomatic hyperamylasemia: odds ratio 2.9 (95 % confidence interval (CI) 1.1 to 7.3, R2 = 0.02).

Conclusions: We did not observe a difference in the rate of pancreatitis between EBD and EST. Asymptomatic hyperamylasemia was observed more frequently after EBD. Although asymptomatic hyperamylasemia is not a clinical entity, this finding may indicate that EBD causes more irritation of the pancreas than EST.