Zusammenfassung: Funktionelle Erkrankungen des Verdauungstraktes sind charakterisiert durch ihre Symptome und das Fehlen struktureller und biochemischer Abnormalitäten, die diese Beschwerden erklären. Dabei bezieht sich das »Fehlen« struktureller und biochemischer Abnormalitäten lediglich auf Befunde, die mit in der klinischen Routine verfügbaren Untersuchungsverfahren erhoben werden können. So weisen neuere Untersuchungen Veränderungen der viszeralen Sensorik nach, die eine wichtige Rolle im Rahmen der Pathophysiologie funktioneller Störungen spielen. Diese Störungen dürften letztlich ebenfalls durch bislang nicht präzise erfasste molekulare, biochemische oder strukturelle Läsionen verursacht oder begünstigt werden.
Summary: Functional disorders of the gastrointestinal tract are characterized by abdominal complaints and gastrointestinal pathological findings which can not be detected by standard diagnostic procedures. Recent research suggests a close etiological association between functional disorders of the gut and modifications of visceral sensitivity caused by molecular, biochemical or structural lesions yet unaccounted for.
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Korrespondenz
Prof. Dr. Gerald Holtmann
Universitätsklinikum Essen, Zentrum
für Innere Medizin, Abteilung für Gastroenterologie
und Hepatologie
Hufelandstraße 55
45122 Essen
Phone: 0201/723 3618
Phone: 0201/723 5970
Email: g.holtmann@uni-essen.de
