Amino Acid Anhydride Hydrochlorides as Acylating Agents in Friedel-Crafts Reaction: A Practical Synthesis of l-Homophenylalanine

Abstract

The use of amino acid anhydride hydrochlorides as acylating agents in Friedel-Crafts reaction is presented for the first time. A practical and convenient route to l-homophenylalanine from l-aspartic acid in 3 steps in 80% overall yield with >99% ee is thus achieved.

Key words

l-aspartic acid - Friedel-Crafts reaction - l-homophenylalanine - l-aspartic anhydride hydrochloride

References

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