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Synlett 2001; 2001(6): 0875-0877
DOI: 10.1055/s-2001-14585
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β-Phenylethylamines, Indolines and Isoquinolones via Hydroamination of Styrenes by Microwave Irradiation

Julio A. Seijas* , M. Pilar Vázquez-Tato, M. Montserrat Martínez
  • *Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Santigao de Compostela, Aptdo. 280, 27080-Lugo, Spain; Fax + 34 982 22 49 04; E-mail: qoseijas@lugo.usc.es or pilarvt@lugo.usc.es
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Publication Date:
31 December 2001 (online)

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Microwave irradiation promotes hydroamination of styrenes. This method can be used as a direct way of producing different kinds of bioactive compounds: open chain compounds like β-phenylethylamines or cyclized products like indolines or isoquinolones.

amination - domino reaction - indoline - isoquinolone - microwave heating - nucleophilic addition - phenethylamine