Download PDF
Synlett 2001; 2001(6): 0833-0835
DOI: 10.1055/s-2001-14588
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Convenient Selective N-Alkylation of 4-Oxo-1,4-dihydro-2-quinoline Carboxylic Acid

Dolorès Edmont* , Jacques Chenault
  • *Institut de Chimie Organique et Analytique, Université d'Orléans, B.P. 6759, 45067 Orléans Cedex 2, France; Fax + 33 2 3841-7281; E-mail: jacques.chenault@univ-orleans.fr
Further Information

Publication History

Publication Date:
31 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

The selective N-alkylation of 4-oxo-1,4-dihydro-2-quinoline carboxylic acid has been achieved from 1,2-dihydro[1,4]oxazino[4,3-a]quinoline-4,6-dione by the 2-morpholinone ring opening. In the same time, we have developed a new methodology to obtain the 1,2-dihydro[1,4]oxazino[4,3-a]quinoline-4,6-dione that involves an intramolecular cyclization of the 2-chloroethyl 6-fluoro-4-oxo, 1,4-dihydro-2-quinoline carboxylate.

N-alkylation - heterocycles - quinolines - ring-opening - intramolecular cyclization