Download PDF
Dtsch Med Wochenschr 2001; 126(Suppl. Gastroenterol. 2): S102-S106
DOI: 10.1055/s-2001-14711
Supplement Gastroenterologie (2)
© Georg Thieme Verlag Stuttgart · New York

Nichtalkoholische Formen der chronischen Pankreatitis[1]

Nonalcoholic forms of chronic pancreatitisP. Layer, J. Keller
  • Abteilung für Innere Medizin (Ärztl. Direktor: Prof. Dr. med. P. Layer), Israelitisches Krankenhaus in Hamburg
Further Information

Publication History

Publication Date:
11 September 2002 (online)

Also available at
    Permissions and Reprints

Alkohol ist die mit 70 - 85 % quantitativ wichtigste Ursache der chronischen Pankreatitis in der westlichen Zivilisation. Die restlichen Fälle werden auf unterschiedliche endogene oder exogene Störungen zurückgeführt [2] [3] [4] [10] [30] [35] [40] [44] . Diese Arbeit gibt einen Überblick über die nichtalkoholischen, klinisch relevanten Ursachen und Formen der chronischen Pankreatitis.

1 Eigene zitierte Studien wurden durch die Deutsche Forschungsgemeinschaft (DFG La 483/5-3) unterstützt.

Literatur

  • 1 Ammann R. Zur vaskulären Genese der chronischen Pankreatitis. Tatsachen und Hypothesen.  Dtsch Med Wschr. 1976;  101 867-868
    Search in Google Scholar
  • 2 Ammann R, Sulser H. Senile chronic pancreatitis; a new nosologic entity? Studies in 38 cases. Indications of a vascular origin and relationship to the primarily painless chronic pancreatitis.  Schweiz Med Wschr. 1976;  106 429-437
    Search in Google Scholar
  • 3 Ammann R W, Akovbiantz A, Largiader F, Schueler G. Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients.  Gastroenterology. 1984;  86 820-828
    Search in Google Scholar
  • 4 Ammann R W, Buehler H, Muench R, Freiburghaus A W, Siegenthaler W. Differences in the natural history of idiopathic (nonalcoholic) and alcoholic chronic pancreatitis. A comparative long-term study of 287 patients.  Pancreas. 1987;  2 368-377
    Search in Google Scholar
  • 5 Bank S, Indaram A. Causes of acute and recurrent pancreatitis. Clinical considerations and clues to diagnosis.  Gastroenterol Clin North Am. 1999;  28 571-589
    Search in Google Scholar
  • 6 Barthet M, Valantin V, Spinosa S, Bernard J P, Sahel J. Clinical course and morphological features of chronic calcifying pancreatitis associated with pancreas divisum.  Eur J Gastroenterol Hepatol. 1995;  7 993-998
    Search in Google Scholar
  • 7 Bradley E L. Chronic obstructive pancreatitis as a delayed complication of pancreatic trauma.  HPB Surg. 1991;  5 49-59
    Search in Google Scholar
  • 8 Cohn J A, Friedman K J, Noone P G, Knowles M R, Silverman L M, Jowell P S. Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis.  N Engl J Med. 1998;  339 653-658
    Search in Google Scholar
  • 9 Cope, Culver P J, Mixter C G, Nardi G L. Pancreatitis, a diagnostic clue to hyperparathyroidism.  Ann Surg. 1957;  145 857-863
    Search in Google Scholar
  • 10 DiMagno E, Clain J E, Layer P. Chronic pancreatitis. Raven Press, New York In: V.L. Go (Ed.), The pancreas: Biology, Pathobiology and Disease 1993 Vol.2: 665-706
    Search in Google Scholar
  • 11 Eisendrath P, Delhaye M, Matos C, Baize M, Cremer M, Deviere J. Prevalence and clinical evolution of isolated ventral pancreatitis in alcoholic chronic pancreatitis.  Gastrointest Endosc. 2000;  51 45-50
    Search in Google Scholar
  • 12 Friess H, Buchler M W, Mueller C, Malfertheiner P. Immunopathogenesis of chronic pancreatitis.  Gastroenterology. 1998;  115 1018-1022
    Search in Google Scholar
  • 13 Frulloni L, Bovo P, Brunelli S, Vaona B, FV, Nishimori I, Cavallini G. Elevated serum levels of antibodies to carbonic anhydrase I and II in patients with chronic pancreatitis.  Pancreas. 2000;  20 382-388
    Search in Google Scholar
  • 14 Frulloni L, Morana G, Bovo P, Mansueto G C, Vaona B, FV, Procacci C, Cavallini G. Salivary gland involvement in patients with chronic pancreatitis.  Pancreas. 1999;  19 33-38
    Search in Google Scholar
  • 15 Gholson C F, Sittig K, Favrot D, McDonald J C. Chronic abdominal pain as the initial manifestation of pancreatic injury due to remote blunt trauma of the abdomen.  South Med J. 1994;  87 902-904
    Search in Google Scholar
  • 16 Goebell H, Horn H D, Bode C, Gossmann H H. Primary hyperparathyroidism and exocrine function of the pancreas. Disturbances of the enzyme and electrolyte secretion in the duodenal juice during a secretin-pancreozymin test.  Klin Wochenschr. 1970;  48 810-819
    Search in Google Scholar
  • 17 Goebell H, Hotz J. Calcium, pancreatic secretion and pancreatitis.  Leber Magen Darm. 1976;  6 211-216
    Search in Google Scholar
  • 18 Hartwig W, Werner J, Ryschich E, Mayer H, Schmidt J, Gebhard M M, Herfarth C, Klar E. Cigarette smoke enhances ethanol-induced pancreatic injury.  Pancreas. 2000;  21 272-278
    Search in Google Scholar
  • 19 Heikius B, Niemela S, Lehtola J, Karttunen T, Lahde S. Pancreatic duct abnormalities and pancreatic function in patients with chronic inflammatory bowel disease.  Scand J Gastroenterol. 1996;  31 517-523
    Search in Google Scholar
  • 20 Horiuchi A, Kawa S, Akamatsu T, Aoki Y, Mukawa K, Furuya N, Ochi Y, Kiyosawa K. Characteristic pancreatic duct appearance in autoimmune chronic pancreatitis: a case report and review of the Japanese literature.  Am J Gastroenterol. 1998;  93 260-263
    Search in Google Scholar
  • 21 Hotz J, Layer P, Goebell H. Calcium and pancreatitis. Elsevier, New York In: K.E. Gyr, M.V. Singer, H. Sarles (Eds.), Pancreatitis - Concepts and Classification 1984 Vol.1: 159-164
    Search in Google Scholar
  • 22 Imoto M, DiMagno E P. Cigarette smoking increases the risk of pancreatic calcification in late-onset but not early-onset idiopathic chronic pancreatitis.  Pancreas. 2000;  21 115-119
    Search in Google Scholar
  • 23 Ito T, Nakano I, Koyanagi S, Miyahara T, Migita Y, Ogoshi K, Sakai H, Matsunaga S, Yasuda O, Sumii T, Nawata H. Autoimmune pancreatitis as a new clinical entity. Three cases of autoimmune pancreatitis with effective steroid therapy.  Dig Dis Sci. 1997;  42 1458-1468
    Search in Google Scholar
  • 24 Keim V, Tannapfel A, Mössner J. Hereditäre Pankreatitis: Pathogenetische Konzepte und Nachweis genetischer Veränderungen.  Deutsches Ärzteblatt. 1998;  95 A2473-2477
    Search in Google Scholar
  • 25 Keller J, Melle U, Hoene K, Daecke W, Groeger G, Layer P. (Abstract).  Pancreas. 2000;  21 453
    Search in Google Scholar
  • 26 Kino-Ohsaki J, Nishimori I, Morita M, Okazaki K, Yamamoto Y, Onishi S, Hollingsworth M A. Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjogren’s syndrome.  Gastroenterology. 1996;  110 1579-1586
    Search in Google Scholar
  • 27 Kloppel G, Maillet B. Pathology of acute and chronic pancreatitis.  Pancreas. 1993;  8 659-670
    Search in Google Scholar
  • 28 Lankisch M R, Imoto M, Layer P, DiMagno E P. The effect of small amounts of alcohol on the clinical course of chronic pancreatitis.  Mayo Clin Proc. 2001;  76 242-251
    Search in Google Scholar
  • 29 Lankisch P G, Layer P. Chronische Pankreatitis: Update - Diagnostik und Therapie 2000.  Deutsches Ärzteblatt. 2000;  97 A2169-2177
    Search in Google Scholar
  • 30 Lankisch P G, Seidensticker F, Lohr-Happe A, Otto J, Creutzfeldt W. The course of pain is the same in alcohol- and nonalcohol-induced chronic pancreatitis.  Pancreas. 1995;  10 338-341
    Search in Google Scholar
  • 31 Laugier R. Endoscopic manometry of the sphincter of Oddi and pancreatic duct in patients with chronic pancreatitis.  Int J Pancreatol. 1997;  21 273-274
    Search in Google Scholar
  • 32 Layer P. Pankreas. Schnetztor Verlag, Konstanz In: C. Ell, H.J. Brambs, W. Fischbach, W.E. Fleig, V. Groß, P. Layer , H. Zirngibl (Eds.), Gastro Update 2000 2000: 89-123
    Search in Google Scholar
  • 33 Layer P. Pankreas. Schnetztor Verlag, Konstanz In: C. Ell, H.J. Brambs, W. Fischbach, W.E. Fleig, V. Groß, P. Layer , H. Zirngibl (Eds.), Gastro Update 2001 2001: im Druck
    Search in Google Scholar
  • 34 Laye P, Balzer K, Goebell H. Hereditary pancreatitis. Presentation of an additional family.  Hepatogastroenterology. 1985;  32 31-33
    Search in Google Scholar
  • 35 Layer P, DiMagno E P. Early and late onset in idiopathic and alcoholic chronic pancreatitis. Different clinical courses.  Surg Clin North Am. 1999;  79 847-860
    Search in Google Scholar
  • 36 Layer P, Goebell H. Calcium homeostasis and exocrine pancreas: physiological and pathological interrelations.  Schweiz Med Wochenschr. 1989;  119 1655-1663
    Search in Google Scholar
  • 37 Layer P, Hotz J, Goebell H. Calcium secretion from the feline pancreas. Influence of hormonal and cholinergic secretagogues and of serum calcium.  Digestion. 1983;  26 89-98
    Search in Google Scholar
  • 38 Layer P, Hotz J, Goebell H. Stimulatory effect of hypercalcemia on pancreatic secretion is prevented by pretreatment with cholecystokinin and cholinergic agonists.  Pancreas. 1986;  1 478-482
    Search in Google Scholar
  • 39 Layer P, Hotz J, Schmitz-Moormann H P, Goebell H. Effects of experimental chronic hypercalcemia on feline exocrine pancreatic secretion.  Gastroenterology. 1982;  82 309-316
    Search in Google Scholar
  • 40 Layer P, Yamamoto H, Kalthoff L, Clain J E, Bakken L J, DiMagno E P. The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis.  Gastroenterology. 1994;  107 1481-1487
    Search in Google Scholar
  • 41 Layer P H, DiMagno E P. Natural histories of alcoholic and idiopathic chronic pancreatitis.  Pancreas. 1996;  12 318-320
    Search in Google Scholar
  • 42 Lehman G A, Sherman S. Diagnosis and therapy of pancreas divisum.  Gastrointest Endosc Clin N Am. 1998;  8 55-77
    Search in Google Scholar
  • 43 Lin Y, Tamakoshi A, Hayakawa T, Ogawa M, Ohno Y. Cigarette smoking as a risk factor for chronic pancreatitis: a case-control study in Japan. Research Committee on Intractable Pancreatic Diseases.  Pancreas. 2000;  21 109-114
    Search in Google Scholar
  • 44 Lowenfels A B, Maisonneuve P, Cavallini G, Ammann R W, Lankisch P G, Andersen J R, DiMagno E P, Andren-Sandberg A, Domellof L, FV. Prognosis of chronic pancreatitis: an international multicenter study. International Pancreatitis Study Group.  Am J Gastroenterol. 1994;  89 1467-1471
    Search in Google Scholar
  • 45 Mixter C G, Keynes W M, Cope O. Further experience with pancreatitis as a diagnostic clue to hyperparathyroidism.  N Engl J Med. 1962;  266 265-272
    Search in Google Scholar
  • 46 Nishimori I, Morita M, Kino J, Onodera M, Nakazawa Y, Okazaki K, Yamamoto Y. Pancreatic involvement in patients with Sjogren’s syndrome and primary biliary cirrhosis.  Int J Pancreatol. 1995;  17 47-54
    Search in Google Scholar
  • 47 Okazaki K, Uchida K, Ohana M, Nakase H, Uose S, Inai M, Matsushima Y, Katamura K, Ohmori K, Chiba T. Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response.  Gastroenterology. 2000;  118 573-581
    Search in Google Scholar
  • 48 Patel R S, Johlin F C, Murray J A. Celiac disease and recurrent pancreatitis.  Gastrointest Endosc. 1999;  50 823-827
    Search in Google Scholar
  • 49 Pfutzer R H, Barmada M M, Brunskill A P, Finch R, Hart P S, Neoptolemos J, Furey W F, Whitcomb D C. SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis.  Gastroenterology. 2000;  119 615-623
    Search in Google Scholar
  • 50 Pitchumoni C S. Chronic pancreatitis: a historical and clinical sketch of the pancreas and pancreatitis.  Gastroenterologist. 1998;  6 24-33
    Search in Google Scholar
  • 51 Sagatelian M A, Fravel J, Gallo S H, Makk L J, Looney S W, Wright R A. Do parotid duct abnormalities occur in patients with chronic alcoholic pancreatitis?.  Am J Gastroenterol. 1998;  93 197-200
    Search in Google Scholar
  • 52 Seibold F, Mork H, Tanza S, Muller A, Holzhuter C, Weber P, Scheurlen M. Pancreatic autoantibodies in Crohn’s disease: a family study.  Gut. 1997;  40 481-484
    Search in Google Scholar
  • 53 Sharer N, Schwarz M, Malone G, Howarth A, Painter J, Super M, Braganza J. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis.  N Engl J Med. 1998;  339 645-652
    Search in Google Scholar
  • 54 Singer M V, Goebell H, Layer P. Pankreatitis. urban & Schwarzenberg, München, Wien, Baltimore In: H. Goebell (Ed.), Gastroenterologie 1992 Vol.1: 485-521
    Search in Google Scholar
  • 55 Tarnasky P R, Hawes R H. Endoscopic diagnosis and therapy of unexplained (idiopathic) acute pancreatitis.  Gastrointest Endosc Clin N Am. 1998;  8 13-37
    Search in Google Scholar
  • 56 Tarnasky P R, Hoffman B, Aabakken L, Knapple W L, Coyle W, Pineau B, Cunningham J T, Cotton P B, Hawes R H. Sphincter of Oddi dysfunction is associated with chronic pancreatitis.  Am J Gastroenterol. 1997;  92 1125-1129
    Search in Google Scholar
  • 57 Teich N, Ockenga J, Hoffmeister A, Manns M, Mossner J, Keim V. Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation.  Gastroenterology. 2000;  119 461-465
    Search in Google Scholar
  • 58 Vestergaard H, Kruse A, Rokkjaer M, Frobert O, Thommesen P, Funch-Jensen P. Endoscopic manometry of the sphincter of Oddi and the pancreatic and biliary ducts in patients with chronic pancreatitis.  Scand J Gastroenterol. 1994;  29 188-192
    Search in Google Scholar
  • 59 Whitcomb D C, Gorry M C, Preston R A, Furey W, Sossenheimer M J, Ulrich C D, Martin S P, Gates L K, Amann S T, Toskes P P, Liddle R, McGrath K, Uomo G, Post J C, Ehrlich G D. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene.  Nat Genet. 1996;  14 141-145
    Search in Google Scholar
  • 60 Witt H, Luck W, Becker M. A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis.  Gastroenterology. 1999;  117 7-10
    Search in Google Scholar
  • 61 Witt H, Luck W, Hennies H C, Classen M, Kage A, Lass U, Landt O, Becker M. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis.  Nat Genet. 2000;  25 213-216
    Search in Google Scholar
  • 62 Yoshida K, Toki F, Takeuchi T, Watanabe S, Shiratori K, Hayashi N. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis.  Dig Dis Sci. 1995;  40 1561-1568
    Search in Google Scholar

Fußnote

1 Eigene zitierte Studien wurden durch die Deutsche Forschungsgemeinschaft (DFG La 483/5-3) unterstützt.

Korrespondenz

Prof. Dr. med. Peter Layer

Abt. für Innere Medizin
Israelitisches Krankenhaus

Orchideenstieg 14

22297 Hamburg

Phone: 040/51125-211

Fax: 040/51125-227

Email: layer@ik-h.de