The aim of the study was to evaluate effects of cardiac natriuretic peptides on splanchnic circulation, especially to the pancreatic islets. Pentobarbital-anesthetized rats were infused intravenously (0.01 ml/min for 20 min] with saline, atrial natriuretic peptide (ANP; 0.25 or 0.5 µg/kg BW/min), brain natriuretic peptide (BNP; 0.5 µg/kg BW/min) or C-type natriuretic peptide (CNP; 0.5 or 2.0 µg/kg BW/min). Splanchnic blood perfusion was then measured with a microsphere technique. Mean arterial blood pressure was decreased by ANP and BNP, but not by CNP. The animals given the highest dose of ANP became markedly hypoglycemic, whilst no such effects were seen in any of the other groups of animals. Total pancreatic blood flow was decreased by the highest dose of CNP, whereas no change was seen after administration of the other peptides. Islet blood flow was increased by the highest dose of ANP. Neither BNP nor CNP affected islet blood flow. None of the natriuretic peptides influenced duodenal, colonic or arterial hepatic blood flow. It is concluded that cardiac natriuretic peptides exert only minor effects on splanchnic blood perfusion in anesthetized rats. However, islet blood perfusion may be influenced by ANP.
Key words:
Splanchnic Organs - Atrial Natriuretic Peptide - Brain Natriuretic Peptide - C-type Natriuretic Peptide - Hypoglycemia
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L. Jansson
Department of Medical Cell Biology
Biomedical Centre
Box 571
SE-751 23 Uppsala
Sweden
eMail: E-mail:Leif.Jansson@medcellbiol.uu.se
