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Pharmacopsychiatry 2001; 34(2): 73-79
DOI: 10.1055/s-2001-15181
Original Paper
© Georg Thieme Verlag Stuttgart · New York

Effects of Risperidone on Event-related Potentials in Schizophrenic Patients

A. Iwanami1 Y. Okajima2 H. Isono2 J. Shinoda2 K. Kasai1 A. Hata1 M. Fukuda3 K. Nakagome2 K. Kamijima2
  • 1 Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo
  • 2 Department of Psychiatry, Showa University School of Medicine
  • 3 Department of Neuropsychiatry, Faculty of Medicine, Gunma University
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Publication History

Publication Date:
31 December 2001 (online)

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In order to examine the effects of risperidone on cognitive impairment in schizophrenia, event-related potentials (ERPs) were recorded before and after switching from conventional neuroleptics to risperidone in schizophrenic patients. ERPs were recorded during two auditory discrimination tasks (an oddball task and a distraction task) in 10 medicated schizophrenic patients during conventional neuroleptic and risperidone treatments. The amplitudes and latencies of N 100 and P 300 component were measured in ERPs for target stimuli in the oddball task and in ERPs for target and novel stimuli in the distraction task. Although N 100 amplitude and latency and P 300 amplitude did not change significantly after switching the drug compared to that during conventional neuroleptic treatment, P 300 latency for target stimuli shortened significantly during risperidone treatment in both tasks, accompanied by the shortening of the reaction time in the distraction task. The P 300 latency change did not correlate with the change of the severity of psychopathology. These findings suggest that risperidone may speed the information processing in schizophrenic patients, contributing to the improvement of cognitive functions.

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Dr. Akira Iwanami

Department of Neuropsychiatry
Faculty of Medicine, University of Tokyo

7-3-1 Hongo

Bunkyoku, Tokyo 113-8655

Japan

Phone: +81-3-3815-5411

Fax: +81-3-5800-6894

Email: iwanami-tky@umin.ac.jp)