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Synthesis 2001(9): 1313-1320
DOI: 10.1055/s-2001-15215
DOI: 10.1055/s-2001-15215
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of N α -Tetrachlorophthaloyl (TCP)-Protected Amino Acids under Microwave Irradiation (MWI)
Weitere Informationen
Received
10 January 2001
Publikationsdatum:
24. September 2004 (online)
Publikationsverlauf
Publikationsdatum:
24. September 2004 (online)
Abstract
A range of N α-tetrachlorophthaloyl protected amino acids have been synthesized by an easy and efficient condensation procedure of the corresponding amino acid and tetrachlorophthaloyl anhydride under irradiation in an unmodified commercial microwave oven.
Key words
amino acids - microwave irradiation - protecting groups - phthalimide - tetrachlorophthaloyl
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References and Notes
PAL, peptide amide linker: 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valeric acid; PEG-PS, polyethylene glycol-polystyrene (graft support).
12Continuous heating resulted in burning of the reaction mixture.