Abstract
In the search of a convenient synthesis for isocordoin (1), a potential anticancer natural product, 2′,4′-dihydroxychalcone was inoculated in cell suspension cultures of Morus nigra, which were expected to contain an active prenyltransferase. After 24 hours the target compound was easily isolated from the metabolite extract. Optimization of the biotransformation resulted in a 85 % yield of the prenyl derivative.
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Dr. G. Delle Monache
Centro Chimica Recettori, C.N.R.
UniversitÈ Cattolica S. Cuore
Largo F. Vito, 1
00168 Roma
Italy
eMail: g.dellemonache@uniserv.ccr.rm.cnr.it
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