A New Tetrahydroprotoberberine N-Oxide Alkaloid and Anti-Platelet Aggregation Constituents of Corydalis tashiroi

Jih-Jung Chen; Ya-Ling Chang; Che-Ming Teng; Wei-Yu Lin; Yu-Chang Chen; Ih-Sheng Chen

doi:10.1055/s-2001-15820

Planta Medica, Inhaltsverzeichnis

Planta Med 2001; 67(5): 423-427
DOI: 10.1055/s-2001-15820

Original Paper

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

A New Tetrahydroprotoberberine N-Oxide Alkaloid and Anti-Platelet Aggregation Constituents of Corydalis tashiroi

Jih-Jung Chen¹ , Ya-Ling Chang² , Che-Ming Teng² , Wei-Yu Lin³ , Yu-Chang Chen³ , Ih-Sheng Chen^3,*

¹ Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
² Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
³ Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Abstract

A new tetrahydroprotoberberine N-oxide alkaloid, (-)-cis-isocorypalmine N-oxide (1), together with two known compounds, 6-methoxydihydrosanguinarine (2) and norjuziphine (3), were isolated in continuing studies of the entire Formosan Corydalis tashiroi plant. The structures of these three compounds were determined through spectral analyses. In addition, compounds 1, 2, 3 and the seven alkaloids previously reported: (-)-cis-corydalmine N-oxide, (-)-trans-corydalmine N-oxide, (-)-trans-isocorypalmine N-oxide, scoulerine, protopine, oxysanguinarine and corydalmine, were found to possess anti-platelet aggregation activity.

Key words

Corydalis tashiroi - Fumariaceae - alkaloids - berberine - tetrahydroprotoberberine N-oxide - (-)-cis-isocorypalmine N-oxide - anti-platelet aggregation activity

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Referenzen

References

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Prof. Dr I. S. Chen

Graduate Institute of

Pharmaceutical Sciences

Kaohsiung Medical University

Kaohsiung

Taiwan

Republic of China

eMail: m635013@cc.kmu.edu.tw

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