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Synlett 2001; 2001(8): 1263-1265
DOI: 10.1055/s-2001-16059
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Multi-Component Synthesis of Imidazo[1,2-a] Annulated Heterocycles on α-Isocyano Resin Esters

Jack J. Chen* , Adam Golebiowski, Sean R Klopfenstein, Joel McClenaghan, Sean X. Peng, David E. Portlock, Laura West
  • *Combinatorial Chemistry Group, Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, OH 45040, USA; Fax (513) 622-23 85; E-mail: chenj1@pg.com
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Publikationsdatum:
31. Dezember 2001 (online)

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The multi-component synthesis of imidazo[1,2-a] annulated heterocycles was performed on the α-isocyano resin esters. This solid phase approach addresses the limited availability issue of isonitrile reagents without compromising the overall diversity of the chemistry.

multi-component condensation - isonitrile resin - combinatorial synthesis - amino acid - 3-amino imidazole