A New and Convenient Synthesis of 1-Aryl-2-dimethylaminoethanols

Miklós Nyerges; Imre Fejes; Andrea Virányi; Paul W. Groundwater; László Töke

doi:10.1055/s-2001-16077

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Synthesis 2001(10): 1479-1482
DOI: 10.1055/s-2001-16077

PAPER

A New and Convenient Synthesis of 1-Aryl-2-dimethylaminoethanols

Miklós Nyerges*^a, Imre Fejes^a, Andrea Virányi^a, Paul W. Groundwater^b, László Töke^a
^a Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, 1521 Budapest P.O.B. 91, Hungary
Fax: +36(1)4633648; e-Mail: nyerges.oct@chem.bme.hu;
^b Institute of Pharmacy and Chemistry, School of Sciences, University of Sunderland, Sunderland SR1 3SD, UK

Further Information

Publication History

Received 8 February 2001
Publication Date:
23 September 2004 (online)

Abstract
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Abstract

An efficient two-step synthesis of 1-aryl-2-dimethylaminoethanols 4 is described, consisting of oxazolidine 3 generation from the cycloaddition of an azomethine ylide to an aldehyde, followed by reductive ring-opening.

Key words

aldehydes - amino alcohols - cycloadditions

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