Abstract
A preparatively simple diastereoselective synthesis of the amino acid chimera (1S ,3S )-1,2,3,4-tetrahydroisoquinoline-1,3-dicarboxylic acid from hexafluoroacetone-protected phenylalanine and glyoxylic acid hydrate via Pictet-Spengler reaction is described. The potential of the reaction of hexafluoroacetone-protected phenylalanine with other aldehydes was scrutinized.
Key words
amino acids - cyclizations - diastereoselectivity - heterocycles - quinolines
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