Collagen, Human Collagen, and Fat: The Search for a Three-Dimensional Soft Tissue Filler

Anthony P. Sclafani; Thomas Romo III

doi:10.1055/s-2001-16368

Facial Plastic Surgery, Inhaltsverzeichnis

Facial Plast Surg 2001; 17(1): 079-085
DOI: 10.1055/s-2001-16368

Collagen, Human Collagen, and Fat: The Search for a Three-Dimensional Soft Tissue Filler

Anthony P. Sclafani^1,3 , Thomas Romo III^2,3

¹Division of Facial Plastic Surgery, The New York Eye and Ear Infirmary, New York, New York
²Facial Plastic Surgery, Lenox Hill Hospital, New York, New York
³New York Medical College, Valhalla, New York

Abstract

ABSTRACT

As the body ages, not only are the soft tissues of the face subject to gravity but they also may undergo progressive atrophy. Suspensory procedures may return the tissues to a more youthful position, but the atrophic changes are left uncorrected and produce an aged appearance. Three-dimensional (3-D) soft tissue fillers ideally would replace the bulk that was lost. Safety, persistence, and verisimilitude to the native tissues should be optimal in useful 3-D fillers. To date, no such material has been described, but there has been a resurgence in natural materials for this purpose. This article serves as an update on human-derived soft tissue fillers.

KEYWORD

Collagen - Cymetra - Dermalogen - fat transfer - soft tissue filler

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Referenzen

REFERENCES

1 Webster R C, Gaunt J M, Hamdan U S, Fuleihan N S, Smith R C. Injectable silicone for facial soft-tissue augmentation. Arch Otolaryngol Head Neck Surg . 1986; 112 290-296
2 Rappaport M J, Vinnik C, Zarem H. Injectable silicone: cause of facial nodules, cellulitis, ulceration and migration. Aesthet Plast Surg . 1996; 20 267-276
3 Ellenbogen R, Rubin L. Injectable fluid silicone therapy, human morbidity and mortality. JAMA . 1975; 234 308-309
4 Klein A W, Wexler P, Carruthers A, Carruthers J. Treatment of facial furrows and rhytids. Dermatol Clin . 1997; 15 595-607
5 Cooperman L S, Mackinnon V, Bechler G, Pharriss B B. Injectable collagen: a six-year clinical investigation. Aesthet Plast Surg . 1985; 9 145-151
6 Cooperman L, Michaeli D. The immunogenicity of injectable collagen. I. A 1-year prospective study. J Am Acad Dermatol . 1984; 10 638-646
7 DeLustro F, Smith S T, Sundsmo J, Salem G, Kinkaid S, Ellingsworth L. Reaction to injectable collagen: results in animal models and clinical use. Plast Reconstr Surg . 1987; 79 581-592
8 Hanke C W. Adverse reactions to bovine collagen. In: Klein AW, ed, Tissue Augmentation in Clinical Practice Procedures and Techniques. New York: Marcel Dekker 1998: 145-154
9 Tolleth H. Long-term efficacy of collagen. Aesthet Plast Surg . 1985; 9 155-158
10 Pieyre J-M. Collagen injections: two years' experience. Aesthet Plast Surg . 1985; 9 153-154
11 Jost G. Experience with collagen injection for the correction of contour deficiencies. Aesthet Plast Surg . 1985; 9 163-165
12 Fagien S. Botox for the treatment of dynamic and hyperkinetic facial lines and furrows: adjunctive use in facial aesthetic surgery. Plast Reconstr Surg . 1999; 103 701-713
13 Sclafani A P, Romo T, Parker A, McCormick S A, Cocker R, Jacono A. Evaluation of autologous collagen dispersion (Autologen) for soft tissue augmentation. Arch Facial Plast Surg . 2000; 2 48-52
14 Sclafani A P, Romo T, Parker A. Homologous collagen dispersion (Dermalogen) as a dermal filler: persistence and histology with comparison to bovine collagen. Presented at the Spring meeting of the American Academy of Facial Plastic Surgery, Palm Desert, CA, May 12, 2001
15 Sclafani A P, McCormick S A, Cocker R. Biophysical and microscopic analysis of homologous dermal and fascial materials for facial aesthetic and reconstructive uses. Arch Facial Plast Surg (in press).
16 Moloney B P. Soft tissue contouring with acellular dermal matrix grafts. Am J Cosmet Surg . 1998; 15 369-380
17 Gryskiewicz J M, Rohrich R J, Reagan B J. The use of AlloDerm for the correction of nasal contour deformities. Plast Reconstr Surg . 2001; 107 561-570
18 Jackson I T, Yavuzer R. AlloDerm for dorsal nasal irregularities. Plast Reconstr Surg . 2001; 107 553-558
19 Achauer B M, VanderKam V M, Celikoz B, Jacobson D G. Augmentation of facial soft-tissue defects with Alloderm dermal graft. Ann Plast Surg . 1998; 41 503-507
20 Castor S A, To W C, Papay F A. Lip augmentation with AlloDerm acellular dermal graft and fat autograft: a comparison with autologous fat injection alone. Aesthet Plast Surg . 1999; 23 218-223
21 Sclafani A P, Romo T, Jacono A, McCormick S A, Cocker R, Parker A. Evaluation of acellular dermal graft in sheet (Alloderm) and injectable (Micronized Alloderm) forms for soft tissue augmentation: clinical results and histologic findings. Arch Facial Plast Surg . 2000; 2 130-136
22 Sclafani A P, Romo T, Jacono A A, McCormick S A, Cocker R, Parker A. Evaluation of acellular dermal graft (AlloDerm) for soft tissue augmentation: one year of clinical observations and histologic findings. Arch Facial Plast Surg . 2001; 3 101-103
23 Neuber F. Fettransplantation. Chir Kong Verhandl Dsch Gesellsch Chir . 1893; 22 66
24 Glogau R G. Microlipoinjection. Arch Dermatol . 1988; 124 1340
25 Pinski K S, Roenigk H H. Autologous fat transplantation: long-term follow-up. J Dermatol Surg Oncol . 1992; 18 179-184
26 Campbell G L, Laudslager N, Newman J. The effect of mechanical stress on adipocyte morphology and metabolism. Am J Cosmet Surg . 1987; 4 89-94
27 Ersek R A. Transplantation of purified autologous fat: a 3-year follow-up is disappointing. Plast Reconstr Surg . 1991; 87 219-227
28 Coleman S R. Facial recontouring with lipostructure. Clin Plast Surg . 1997; 24 347-367