Planta Med 2001; 67(6): 528-532
DOI: 10.1055/s-2001-16489
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antiviral, Haemolytic and Molluscicidal Activities of Triterpenoid Saponins from Maesa lanceolata: Establishment of Structure-Activity Relationships

Sandra Apers1,*, Slavka Baronikova1 , Jean-Bosco Sindambiwe1 , Myriam Witvrouw2 , Erik De Clercq2 , Dirk Vanden Berghe1 , Eric Van Marck3 , Arnold Vlietinck1 , Luc Pieters1
  • 1 Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
  • 2 Rega Institute for Medical Research, Leuven, Belgium
  • 3 Department of Medicine, University of Antwerp, Antwerp, Belgium
Further Information

Publication History

August 18, 2000

January 6, 2001

Publication Date:
17 August 2001 (online)

Abstract

Ten saponins isolated from the leaves of Maesa lanceolata were tested for their antiviral, haemolytic and molluscicidal activities. The influence of the substitution pattern of these acylated triterpenoid saponins on their biological activities was investigated and structure-activity relationships were established. Maesasaponin VI2 (3β-O-{[α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucopyranuronyl}-21β,22α-diangeloyloxy-13 β,28-epoxyolean-16α,28α-diol), the most potent molluscicidal compound (LC50 0.5 ppm), also showed virucidal and haemolytic activity. In general, 21,22-diacylation appeared to be associated with a virucidal (reduction factor of the viral titer ≥ 103 at 50 μg/ml) and haemolytic activity (HC50 ≤ 1 μg/ml).

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Sandra Apers

Department of Pharmaceutical Sciences

University of Antwerp (UIA)

Universiteitsplein 1

2610 Antwerp

Belgium

Email: Sandra.Apers@ua.ac.be

Fax: +32-3-820-27 09