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DOI: 10.1055/s-2001-16496
© Georg Thieme Verlag Stuttgart · New York
Extracts from Fruits of Saw Palmetto (Sabal serrulata) and Roots of Stinging Nettle (Urtica dioica): Viable Alternatives in the Medical Treatment of Benign Prostatic Hyperplasia and Associated Lower Urinary Tracts Symptoms
Publication History
September 29, 2000
March 10, 2001
Publication Date:
17 August 2001 (online)
![](https://www.thieme-connect.de/media/plantamedica/200106/lookinside/thumbnails/10.1055-s-2001-16496-1.jpg)
Abstract
Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are very common disorders in aging men. Despite the great clinical importance, many aspects of their aetiology remain uncertain although it is generally accepted that advanced age and testicular androgens are important requirements for the development of these complaints. The currently available therapeutic options include watchful waiting, changes of life style, medical treatments and invasive therapies. In many European countries the use of phytopharmaceuticals for the management of BPH and related LUTS is common and these products represent up to 80 % of all drugs prescribed for this disorder. In particularly, extracts from the fruits of saw palmetto (Sabal serrulata, syn. Serenoa repens) and the roots of stinging nettle (Urtica dioica) are popular. During the last years numerous papers have been published which elaborated on the pharmacological activities and the clinical assessment of these herbal remedies. These investigations have not only broadened the scientific basis for the rational use of phytotherapeutics but have also provided evidence for their therapeutic efficacy and favourable safety profile.
Abbreviations
AR:androgen receptor
bFGF:basic fibroblast growth factor
BPH:benign prostatic hyperplasia
CK:creatine kinase
DHT:dihydrotestosterone
EGF:epidermal growth factor
ER:estrogen receptor
HLE:human leukocyte elastase
HPLC:high pressure liquid chromatography
HSOR:hydroxysteroid oxidoreductase
IGF:insulin-like growth factor
IPSS:international prostate symptome scale
LTB4:leukotriene B4
LUTS:lower urinary tract symptoms
p.o.:per os
PDGF:platelet-derived growth factor
PgR:progesterone receptor
PLA2:phospholipase A2
PRL:prolactin
SHBG:sex hormone-binding globulin
SNRE:stinging nettle root extract
SPFE:saw palmetto fruit extract
TGF:transforming growth factor
TXB2:thromboxan B2
UDA:Urtica dioica agglutinin
UGS:urogenital sinus
Key words
Benign prostatic hyperplasia - lower urinary tract symptoms - phytopharmaceuticals - pharmacology - clinic - Sabal serrulata - Serenoa repens - Urtica dioica - saw palmetto - stinging nettle
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Dr. Egon Koch
Department of Pharmacology
Dr. Willmar Schwabe Arzneimittel GmbH
Willmar-Schwabe-Straße 4
76227 Karlsruhe
Germany
Email: egon.koch@schwabe.de
Fax: +49(0)721-4005 150