Solution- and Solid-Phase Approaches in Asymmetric Phase-Transfer Catalysis by Cinchona Alkaloid Derivatives

Baptiste Thierry; Thierry Perrard; Christophe Audouard; Jean-Christophe Plaquevent; Dominique Cahard

doi:10.1055/s-2001-16749

SPECIALTOPIC

Solution- and Solid-Phase Approaches in Asymmetric Phase-Transfer Catalysis by Cinchona Alkaloid Derivatives

Baptiste Thierry, Thierry Perrard, Christophe Audouard, Jean-Christophe Plaquevent*, Dominique Cahard*
UMR 6014 de l"IRCOF (Institut de Recherche en Chimie Organique Fine), Université de Rouen, 76821 Mont Saint Aignan Cedex, France
Fax: +(33)235522971; e-Mail: jean-christophe.plaquevent@univ-rouen.fr; dominique.cahard@univ-rouen.fr;

Abstract

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Abstract

The catalytic asymmetric alkylation under phase-transfer conditions of various substrates (enones, α-fluoro ketones, glycine-imines) promoted by chiral quaternary ammonium salts derived from cinchona alkaloids is described. A solvent-free phase-transfer catalysis is presented as well as a new type of polymer-supported phase-transfer catalyst derived from cinchona alkaloids.

Key words

phase-transfer catalysis - polymers - Michael addition - fluorine - asymmetric catalysis

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References

Selected articles:

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