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Synthesis 2001(11): 1627-1630
DOI: 10.1055/s-2001-16752
PAPER
© Georg Thieme Verlag Stuttgart · New York

Facile Chemical Syntheses of Porphobilinogen Analogues: A Four-Step Synthesis to iso-Porphobilinogen

Kwai-Ming Cheung, Peter M. Shoolingin-Jordan*
Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK
Fax: +44(0)2380594459; e-Mail: pmsj@soton.ac.uk;
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Publication History

Received 1 March 2001
Publication Date:
28 September 2004 (online)

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Abstract

iso-Porphobilinogen was prepared in four good yielding steps, as well as a group of iso-porphobilinogen analogues, using a modification of Zav’yalov’s method.

Key words

iso-porphobilinogen - 5-aminolevulinic acid - tetrapyrroles - diethyl opsopyrroledicarboxylate - porphobilinogen