Download PDF
Synlett 2001; 2001(9): 1467-1469
DOI: 10.1055/s-2001-16781
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of Structurally Diversified α-Substituted β-Amino Acids and Derivatives via Conjugate Radical Additions and Heck Reactions

Jacques Huck* , Jean-Marie Receveur, Marie-Louise Roumestant, Jean Martinez
  • *Laboratoire des Aminoacides, Peptides et Protéines, UMR CNRS 5810, Universités Montpellier I & II, 2 Place E. Bataillon, 34095 Montpellier Cedex 05, France; Fax (33)04 67 14 48 66; E-mail: recevej@netscape.net
Further Information

Publication History

Publication Date:
28 August 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

An efficient short-step synthesis of α-substituted β-amino, β-hydrazino, β-N-hydroxy esters and β-urethane N-carboxyanhydrides is reported. Structural diversity was easily incorporated in good yields at the α position of the carboxylic group via conjugate radical additions and Heck reactions performed on the conjugated double bond of synthons 3, 8 and 9.

α-substituted β-amino acids - radical addition - Heck reaction - β-UNCAs