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DOI: 10.1055/s-2001-17349
New Sesquiterpene Lactones from Elephantopus mollis and Their Leishmanicidal Activities
Publikationsverlauf
September 1, 2000
December 15, 2000
Publikationsdatum:
24. September 2001 (online)
Abstract
The leishmanicidal compounds isolated from whole plants of Elephantopus mollis H.B.K. were identified as follows. Three new sesquiterpenoid lactones, 2,5-epoxy-2β-hydroxy-8α-(2-methylpropenoyloxy)-4(15),10(14),11(13)-germacratrien-12,6α-olide, (4βH)-8α-(2-methylpropenoyloxy)-2-oxo-1(5),10(14), 11(13)-guaiatrien-12,6α-olide and (4βH)-5α-hydroxy-8α-(2-methylpropenoyloxy)-1(10),11(13)-guaiadiene-12,6α-olide, were isolated from Peruvian and Brazilian collections together with four known sesquiterpenoids, molephantin, elephantopin, isoelephantopin and 2-deethoxy-2β-methoxyphantomolin. They exhibited potent in vitro leishmanicidal activities against Leishmania major. The α-methylene-γ-butyrolactone moiety was found to be essential to the potent leishmanicidal effect observed.
Key words
Sesquiterpenes - Elephantopus mollis - Compositae - leishmaniasis - Leishmania major