Triterpene Constituents from the Stem Bark of Pinus luchuensis and their DNA Topoisomerase II Inhibitory Effect

Abstract

Nine lanostane and serratane-type triterpenes including two unknown compounds were isolated from the stem bark of Pinus luchuensis. These new compounds were characterized as 3-oxolanost-9(11)-ene-24S,25-diol (1) and 29-acetoxy-3β-methoxyserrat-14-en-21α-ol (2) on the basis of spectroscopic evidence. Some of these triterpenes were tested for the inhibitory effect on DNA topoisomerase II activity. Compound 1 showed a slightly less potent inhibitory activity with an IC₅₀ value of 186 μM.

Key words

Pinus luchuensis - Pinaceae - triterpene, 3-oxolanost-9 (11)-ene-24S,25-diol, 29-acetoxy-3β-methoxyserrat-14-en-21α-ol - DNA topoisomerase II

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