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DOI: 10.1055/s-2001-17363
© Georg Thieme Verlag Stuttgart · New York
Topical Anti-Inflammatory Activity of a New Germacrane Derivative from Achillea pannonica
Publikationsverlauf
October 17, 2000
January 7, 2001
Publikationsdatum:
24. September 2001 (online)
![](https://www.thieme-connect.de/media/plantamedica/200107/lookinside/thumbnails/10.1055-s-2001-17363-1.jpg)
Abstract
The topical anti-inflammatory activity of a germacrane derivative [1,4-dihydroxy-germacra-5E-10(14)-diene; DHGD] isolated from Achillea pannonica Scheele (Asteraceae) was investigated employing the Croton oil-induced dermatitis in the mouse ear. Its effects on the oedematous response and on leukocytes infiltration are described. The germacrane derivative significantly inhibited ear oedema in a dose-dependent manner, with an ID50 of 0.40 μmol/cm2. DHGD (0.75 μmol/cm2) provoked a global inhibition of the oedematous response (61 %) higher than that induced by an equimolar dose of indomethacin (43 %) within 24 hours; the reduction induced by hydrocortisone (0.10 μmol/cm2) was 68 %. The effect of DHGD (61 % inhibition) was higher than that of the equimolar dose of indomethacin (51 % inhibition) also on granulocytes recruitment at the site of inflammation. Hydrocortisone (0.10 μmol/cm2) reduced the cellular infiltrate by 44 %.
Key words
Achillea pannonica - Asteraceae - sesquiterpene - germacrane - anti-inflammatory activity - Croton oil
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Prof. Roberto Della Loggia
DEMREP - University of Trieste
Via A. Valerio, 6
34127 Trieste
Italy
eMail: roberto.della.loggia@econ.univ.trieste.it
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