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Synlett 2001; 2001(10): 1602-1604
DOI: 10.1055/s-2001-17440
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A Sulfone-mediated Synthesis of (+)-Preussin

John J. Caldwell* , Donald Craig, Stephen P. East
  • *Centre for Chemical Synthesis, Department of Chemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK; Fax + 44(20)75 94 58 68; E-mail: d.craig@ic.ac.uk
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Publication Date:
27 September 2001 (online)

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The synthesis of the antifungal pyrrolidine (+)-preussin is described, utilising the 5-endo-trig cyclisation of a vinylic sulfone generated in situ to give the requisite pyrrolidine nucleus.

cyclisation - natural products - stereoselectivity - sulfones - total synthesis