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Synlett 2001; 2001(10): 1516-1518
DOI: 10.1055/s-2001-17455
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Synthesis of a PNA-Peptide Conjugate by Chemical Ligation

Martijn C. de Koning* , Dmitri V. Filippov, Nico Meeuwenoord, Mark Overhand, Gijsbert A. van der Marel, Jacques H. van Boom
  • *Leiden Institute of Chemistry, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Fax + 31(71)52 74 30; E-mail: j.boom@chem.leidenuniv.nl
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Publication Date:
27 September 2001 (online)

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A convergent synthetic route to the construction of a PNA-N-to-C-peptide conjugate (PKKKRKVGC-ttgcatt) by regioselective condensation of a thioester peptide and a cysteine-PNA adduct under denaturating conditions is described.

native chemical ligation - PNA-peptide conjugate - nuclear localization signal - convergent synthesis