Dokumentierte Infektionen bei Neutropenie - Empfehlungen zu Diagnostik und Therapie

Vorbemerkung

Standardempfehlungen und Leitlinien der »Arbeitsgemeinschaft Infektionen in der Hämatologie und Onkologie« der Deutschen Gesellschaft für Hämatologie und Onkologie (DGHO) zu Diagnostik und Therapie von Fieber unklarer Genese [23], Pilzinfektionen [3], Infektionen nach Hochdosistherapie und autologer Stammzelltransplantation [28], Sepsis in der Neutropenie [37], Venenkatheter-assoziierten Infektionen [11], Lungeninfiltraten bei neutropenischen Patienten [27] und zur Infektionsprophylaxe [20] wurden bereits in der DMW publiziert.

Literatur

• 1 Anand A, Glatt A E. Clostridium difficile infection associated with antineoplastic chemotherapy: a review.  Clin Infect Dis. 1993;  17 109-113
• 2 Bochud P Y, Calandra T, Francioli P. Bacteremia due to viridans streptococci in neutropenic patients: a review.  Am J Med. 1994;  97 256-264
• 3 Böhme A, Karthaus M, Einsele H. et al . Diagnostik systemischer Pilzinfektionen in der Hämatologie.  Dtsch Med Wochenschr. 1999;  124 S24-30
• 4 Caplan E S, Hoyt N J. Nosocomial sinusitis.  JAMA. 1982;  247 639-641
• 5 Chirletti P, Barillari P, Sammartino P. et al . The surgical choice in neutropenic patients with hematological disorders and acute abdominal complications.  Leuk Lymphoma. 1993;  9 237-241
• 6 Denning D W, Evans E G, Kibbler C C. et al . Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation.  Eur J Clin Microbiol Infect Dis. 1997;  16 424-436
• 7 deShazo R D, Chapin K, Swain R E. Fungal sinusitis.  N Engl J Med. 1997;  337 254-259
• 8 Drakos P E, Nagler A, Or R. et al . Invasive fungal sinusitis in patients undergoing bone marrow transplantation.  Bone Marrow Transplant. 1993;  12 203-208
• 9 Elting L S, Rubenstein E B, Rolston K V. et al . Outcomes of bacteremia in patients with cancer and neutropenia: observations from two decades of epidemiological and clinical trials.  Clin Infect Dis. 1997;  25 247-259
• 10 Escande M C, Herbrecht R. Prospective study of bacteraemia in cancer patients. Results of a French multicentre study.  Support Care Cancer. 1998;  6 273-280
• 11 Fätkenheuer G, Buchheidt D, Fuhr H G. et al . Venenkatheter-assoziierte Infektionen bei Patienten mit Neutropenie.  Dtsch Med Wochenschr. 2001;  126 89-95
• 12 Gerding D N, Johnson S, Peterson L R, Mulligan M E, Silva J . Society for Healthcare and Epidemiology of America: position paper on Clostridium difficile-associated diarrhea and colitis.  Infect Control Hosp Epidemiol. 1995;  16 459-477
• 13 Gillespie M B, O’Malley B WJ, Francis H W. An approach to fulminant invasive fungal rhinosinusitis in the immunocompromised host.  Arch Otolaryngol Head Neck Surg. 1998;  124 520-526
• 14 Guppy K H, Thomas C, Thomas K, Anderson D. Cerebral fungal infections in the immunocompromised host: a literature review and a new pathogen-Chaetomium atrobrunneum: case report.  Neurosurgery. 1998;  43 1463-1469
• 15 Hagensee M E, Bauwens J E, Kjos B, Bowden R A. Brain abscess following marrow transplantation: experience at the Fred Hutchinson Cancer Research Center, 1984 - 1992.  Clin Infect Dis. 1994;  19 402-408
• 16 Hughes W T, Armstrong D, Bodey G P, Brown A E, Edwards J E, Feld R, Pizzo P, Rolston K V, Shenep J L, Young L S. 1997 guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Infectious Diseases Society of America.  Clin Infect Dis. 1997;  25 551-573
• 17 Iino T, Gondo H, Ohno Y. et al . Successful foscarnet therapy for mucocutaneous infection with Herpes simplex virus in a recipient after unrelated bone marrow transplantation.  Bone Marrow Transplant. 1996;  18 1185-1188
• 18 Jacobs L G. Fungal urinary tract infections in the elderly: treatment guidelines.  Drugs Aging. 1996;  8 89-96
• 19 Kennedy C A, Adams G L, Neglia J P, Giebink G S. Impact of surgical treatment on paranasal fungal infections in bone marrow transplant patients.  Otolaryngol Head Neck Surg. 1997;  116 610-616
• 20 Kern W V, Beyer J, Böhme A. et al . Infektionsprophylaxe bei neutropenischen Patienten.  Dtsch Med Wochenschr. 2000;  125 1582-1588
• 21 Kyne L, Warny M, Qamar A, Kelly C P. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A.  N Engl J Med. 2000;  342 390-397
• 22 Lazarus H M, Belanger R, Candoni A, Aoun M, Jurewicz R, Marks L. Intravenous penciclovir for treatment of Herpes simplex infections in immunocompromised patients: results of a multicenter, acyclovir-controlled trial.  Antimicrob Agents Chemother. 1999;  43 1192-1197
• 23 Link H, Blumenstengel K, Böhme A. et al . Antimikrobielle Therapie von unerklärtem Fieber bei Neutropenie.  Dtsch Med Wochenschr. 1999;  124 S3-S8
• 24 Link H, Maschmeyer G, Meyer P. et al . Interventional antimicrobial therapy in febrile neutropenic patients.  Ann Hematol. 1994;  69 231-243
• 25 Loyer E M, DuBrow R A, David C L, Coan J D, Eftekhari F. Imaging of superficial soft-tissue infections: sonographic findings in cases of cellulitis and abscess.  Am J Roentgenol. 1996;  166 149-152
• 26 Maschmeyer G. Interventional antimicrobial therapy in febrile neutropenic patients.  Diagn Microbiol Infect Dis. 1999;  34 205-212
• 27 Maschmeyer G, Beinert T, Buchheidt D, Einsele H, Holler E. Diagnostik und Therapie von Lungeninfiltraten bei febrilen neutropenischen Patienten.  Dtsch Med Wochenschr. 1999;  124 S18-S23
• 28 Maschmeyer G, Hertenstein B, Glass B, Schiel X. Interventionelle antimikrobielle Therapie febriler Komplikationen nach Hochdosistherapie und autologer Stammzelltransplantation.  Dtsch Med Wochenschr. 1999;  124 S9-13
• 29 Maschmeyer G, Hiddemann W, Link H. et al . Management of infections during intensive treatment of hematologic malignancies.  Ann Hematol. 1997;  75 9-16
• 30 Matsumoto T, Takahashi K, Tanaka M, Kumazawa J. Infectious complications of combination anticancer chemotherapy for urogenital cancers.  Int Urol Nephrol. 1999;  31 7-14
• 31 McFarland L V, Mulligan M E, Kwok R Y, Stamm W E. Nosocomial acquisition of Clostridium difficile infection.  N Engl J Med. 1989;  320 204-210
• 32 Montalban C, Patier J L, Calleja J L, Perales J, Serrano M, Bellas C. Neutropenic enterocolitis during treatment of lymphoproliferative neoplasms.  Med Clin (Barc). 1989;  93 649-652
• 33 Morgan M A, Wilson W R, Neel H B, Roberts G D. Fungal sinusitis in healthy and immunocompromised individuals.  Am J Clin Pathol. 1984;  82 597-601
• 34 Nadel D M, Lanza D C, Kennedy D W. Endoscopically guided cultures in chronic sinusitis.  Am J Rhinol. 1998;  12 233-241
• 35 Nguyen-Van-Tam S E, Nguyen-Van-Tam J S, Myint S, Pearson J C. Risk factors for hospital-acquired urinary tract infection in a large English teaching hospital: a case-control study.  Infection. 1999;  27 192-197
• 36 Nielsen H, Daugaard G, Tvede M, Bruun B. High prevalence of Clostridium difficile diarrhoea during intensive chemotherapy for disseminated germ cell cancer.  Br J Cancer. 1992;  66 666-667
• 37 Ostermann H, Derigs H G, Heussel G. et al . Sepsis in Neutropenie.  Dtsch Med Wochenschr. 1999;  124 S14-S17
• 38 Patchell R A, Posner J B. Neurologic complications of systemic cancer.  Neurol Clin. 1985;  3 729-750
• 39 Peterson K L, Wang M, Canalis R F, Abemayor E. Rhinocerebral mucormycosis: evolution of the disease and treatment options.  Laryngoscope. 1997;  107 855-862
• 40 Pizzo P A, Ladisch S, Ribichaud K. Treatment of gram-positive septicemia in cancer patients.  Cancer. 1980;  45 206-207
• 41 Shamberger R C, Weinstein H J, Delorey M J, Levey R H. The medical and surgical management of typhlitis in children with acute nonlymphocytic (myelogenous) leukemia.  Cancer. 1986;  57 603-609
• 42 Shim J K, Johnson S, Samore M H, Bliss D Z, Gerding D N. Primary symptomless colonisation by Clostridium difficile and decreased risk of subsequent diarrhoea.  Lancet. 1998;  351 633-636
• 43 Teasley D G, Gerding D N, Olson M M. et al . Prospective randomised trial of metronidazole versus vancomycin for Clostridium-difficile-associated diarrhoea and colitis.  Lancet. 1983;  2 1043-1046
• 44 von Herbay A, Möller P, Ludwig W, Otto H F. Neutropenische Enterocolitis.  Dtsch Med Wochenschr. 1989;  114 293-297
• 45 Wade D S, Nava H R, Douglass H OJ. Neutropenic enterocolitis. Clinical diagnosis and treatment.  Cancer. 1992;  69 17-23
• 46 Yuen K Y, Woo P C, Liang R H. et al . Clinical significance of alimentary tract microbes in bone marrow transplant recipients.  Diagn Microbiol Infect Dis. 1998;  30 75-81

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