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Horm Metab Res 2001; 33(10): 612-617
DOI: 10.1055/s-2001-17909
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Triglyceride-Rich Lipoprotein Cholesterol Exceeds Low-Density Lipoprotein Cholesterol in Hypertriglyceridemia Patients

M. Ai1 , A. Tanaka1 , N. Tomie1 , K. Ogita2 , M. Sekine2 , F. Numano2 , F. Numano1
  • 1 Third Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
  • 2 Department of Internal Medicine, Tokyo Metropolitan Kiyose Hospital, Tokyo, Japan
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Publication History

Publication Date:
18 October 2001 (online)

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The atherogenicity of triglyceride-rich lipoprotein has been revealed. This study was performed to explore the clinical importance of triglyceride-rich lipoprotein by measuring its cholesterol content and comparing it with other lipoprotein fractions. Blood samples were obtained from 103 patients whose fasting plasma triglyceride concentration exceeded 300 mg/dl. The cholesterol monitor using the technique of high-performance liquid chromatography was used for the measurement of their plasma cholesterol concentrations and the determination of cholesterol distribution among lipoprotein fractions. This monitor showed 4 peaks: large-triglyceride-rich lipoprotein, small-triglyceride-rich lipoprotein, low-density lipoprotein, and high-density lipoprotein. Total cholesterol increased with increasing triglyceride. The increment of total cholesterol was nearly equal to that of small-triglyceride-rich lipoprotein cholesterol. Small-triglyceride-rich lipoprotein cholesterol exceeded low-density lipoprotein cholesterol where plasma triglyceride concentration was over 500 mg/dl. In conclusion, triglyceride-rich lipoprotein may be clinically important for hypertriglyceridemic patients as a source of cholesteryl ester in arteriosclerotic plaques, and increased triglyceride-rich lipoprotein cholesterol may be used as a basis for hypertriglyceridemia atherogenicity. Our study suggests that hypertriglyceridemia should be treated to prevent arteriosclerotic disease.

Key words:

Triglyceride - Hypercholesterolemia - Hypertriglyceridemia - Triglyceride-Rich Lipoprotein - Arteriosclerosis - Apolipoprotein

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Akira Tanaka, M.D.

Third Department of Internal Medicine
Tokyo Medical and Dental University

1-5-45, Yushima, Bunkyo-ku
Tokyo 113-8519
Japan


Phone: + 81 (3) 5803-5228

Fax: + 81 (3) 5803-5228

Email: tanaka.med3@tmd.ac.jp